Signaling specificity in the Akt pathway in biology and disease
A Toker, S Marmiroli - Advances in biological regulation, 2014 - Elsevier
Akt/PKB is a key master regulator of a wide range of physiological functions including
metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. The …
metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. The …
The Akt kinases: isoform specificity in metabolism and cancer
E Gonzalez, TE McGraw - Cell cycle, 2009 - Taylor & Francis
The Akt (PKB) protein kinases are critical regulators of human physiology that control an
impressive array of diverse cellular functions, including the modulation of growth, survival …
impressive array of diverse cellular functions, including the modulation of growth, survival …
Akt signalling in health and disease
I Hers, EE Vincent, JM Tavaré - Cellular signalling, 2011 - Elsevier
Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …
Akt/PKB: one kinase, many modifications
G Risso, M Blaustein, B Pozzi, P Mammi… - Biochemical …, 2015 - portlandpress.com
Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the
regulation of a plethora of cellular processes triggered by a wide diversity of extracellular …
regulation of a plethora of cellular processes triggered by a wide diversity of extracellular …
Intracellular signaling by Akt: bound to be specific
TF Franke - Science signaling, 2008 - science.org
Over the past decade, the serine/threonine kinase Akt (also known as protein kinase B) has
emerged as a critical signaling molecule within eukaryotic cells. In addition to the research …
emerged as a critical signaling molecule within eukaryotic cells. In addition to the research …
A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities
A Bellacosa, JR Testa, R Moore… - Cancer biology & therapy, 2004 - Taylor & Francis
More than a decade after their discovery, the three AKT kinase family members have
emerged as central players in the signaling cascades that regulate cell growth, proliferation …
emerged as central players in the signaling cascades that regulate cell growth, proliferation …
The Role of the Dysfunctional Akt‐Related Pathway in Cancer: Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future …
G Romano - Scientifica, 2013 - Wiley Online Library
Akt serine/threonine kinases, or PKB, are key players in the regulation of a wide variety of
cellular activities, such as growth, proliferation, protection from apoptotic injuries, control of …
cellular activities, such as growth, proliferation, protection from apoptotic injuries, control of …
[HTML][HTML] Akt isoforms in vascular disease
The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1,
Akt2 and Akt3. Akt activation has been implicated in both normal and disease processes …
Akt2 and Akt3. Akt activation has been implicated in both normal and disease processes …
AKT signaling in physiology and disease
KM Vasudevan, LA Garraway - Phosphoinositide 3-kinase in Health and …, 2011 - Springer
The serine/threonine kinase AKT functions as a critical mediator of signaling downstream of
PI3 kinase. Studies over the last two decades have firmly established the importance of AKT …
PI3 kinase. Studies over the last two decades have firmly established the importance of AKT …
Achieving specificity in Akt signaling in cancer
A Toker - Advances in biological regulation, 2012 - Elsevier
Since it's discovery as an effector of PI 3-K (phosphoinositide 3-kinase)(Franke et al., 1995),
the serine/threonine kinase Akt (also known as PKB, protein kinase B) has emerged as a …
the serine/threonine kinase Akt (also known as PKB, protein kinase B) has emerged as a …