Background Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-
ischaemia. We did a multicentre randomised controlled trial to find out if delayed head …

Background Moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy
might improve survival and neurological outcomes at up to 18 months of age, although …

Objective To determine whether moderate hypothermia after hypoxic-ischaemic
encephalopathy in neonates improves survival and neurological outcome at 18 months of …

Objectives. To determine the neurodevelopmental outcome of infants treated with head
cooling with systemic hypothermia after hypoxic-ischemic encephalopathy. Study Group …

In term infants with HIE there is emerging evidence that both selective head cooling and
whole body cooling are neuroprotective and safe. This is consistent with a wealth of …

Background The objective of this study was to systematically review randomized trials
assessing therapeutic hypothermia as a treatment for term neonates with hypoxic ischemic …

OBJECTIVE. The goal of this study was to evaluate the role of factors that may determine the
efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Background We previously reported early results of a randomized trial of whole-body
hypothermia for neonatal hypoxic–ischemic encephalopathy showing a significant reduction …