Oxymatrine: A current overview of its health benefits

DQ Huan, NQ Hop, NT Son - Fitoterapia, 2023 - Elsevier
Oxymatrine (OMT), was identified as a quinolizidine alkaloid, which was one of the major
matrine-type alkaloids extracted from Sophora medicinal plants. Growing studies revealed …

Anti-tumor activities of matrine and oxymatrine: literature review

Y Liu, Y Xu, W Ji, X Li, B Sun, Q Gao, C Su - Tumor Biology, 2014 - Springer
Matrine (MT) and oxymatrine (OMT), two kinds of alkaloid components found in the roots of
Sophora species, have various pharmacological activities and are demonstrated to have …

Gastroprotective and anti‐ulcer effects of oxymatrine against several gastric ulcer models in rats: Possible roles of antioxidant, antiinflammatory, and prosurvival …

Y Fu, H Wu, H Cui, Y Li, C Li - Phytotherapy Research, 2018 - Wiley Online Library
Oxymatrine (OXY) has antioxidative and antiinflammatory activities. In the present work, we
investigate the effects of OXY on gastric ulcer models and elucidate the underlying …

RETRACTED: Effects of oxymatrine on the proliferation and apoptosis of human hepatoma carcinoma cells

Y Liu, T Bi, W Dai, G Wang, L Qian, Q Gao, G Shen - 2016 - journals.sagepub.com
Oxymatrine, one of the main active components of extracts from the dry roots of Sophora
flavescens, has been reported to possess anticancer activities in vitro and in vivo. However …

Oxymatrine Extracted from Sophora flavescens Inhibited Cell Growth and Induced Apoptosis in Human Osteosarcoma MG-63 Cells In Vitro

J Wei, Y Zhu, G Xu, F Yang, Z Guan, M Wang… - Cell biochemistry and …, 2014 - Springer
Oxymatrine, one of the most active components of the ethanol extracts from Sophora
flavescens, is known for its potent antitumor activity both in vitro and in vivo. However, the …

Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism (s) in tumor models

CE Halim, SL Xinjing, L Fan, JB Vitarbo, F Arfuso… - Pharmacological …, 2019 - Elsevier
Oxymatrine (OMT) is a quinolizidine alkaloid derived from the roots of the Sophora genus
plants. It has been widely used as a treatment for chronic hepatitis infections and …

Oxymatrine and insulin resistance: Focusing on mechanistic intricacies involve in diabetes associated cardiomyopathy via SIRT1/AMPK and TGF‐β signaling pathway

S Seksaria, S Mehan, BJ Dutta… - … of Biochemical and …, 2023 - Wiley Online Library
Cardiomyopathy (CDM) and related morbidity and mortality are increasing at an alarming
rate, in large part because of the increase in the number of diabetes mellitus cases. The …

Oxymatrine synergistically enhances antitumor activity of oxaliplatin in colon carcinoma through PI3K/AKT/mTOR pathway

Y Liu, T Bi, Z Wang, G Wu, L Qian, Q Gao, G Shen - Apoptosis, 2016 - Springer
Oxymatrine (OMT), one of the main active components of extracts from the dry roots of
Sophora flavescens, has been reported to possess many pharmacological properties …

[HTML][HTML] Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo

C Wu, W Huang, Y Guo, P Xia… - Molecular …, 2015 - spandidos-publications.com
Oxymatrine is an alkaloid, which is derived from the traditional Chinese herb, Sophora
flavescens Aiton. Oxymatrine has been shown to exhibit anti‑inflammatory, antiviral, and …

Oxymatrine targets EGFRp-Tyr845 and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells

B Guo, T Zhang, J Su, K Wang, X Li - Cancer chemotherapy and …, 2015 - Springer
Purpose Oxymatrine (matrine oxide, matrine N-oxide, matrine 1-oxide) is one of the
quinolizidine alkaloid compounds extracted from the root of Sophora flavescens (a …