We tested the hypothesis that kisspeptin cells constitute the “pulse generator” for GnRH
secretion. In ewes, we determined whether iv administered kisspeptin elicits a secretory …

Pulsatile release of gonadotrophin‐releasing hormone (GnRH) is indispensable to maintain
normal gonadotrophin secretion. The pulsatile secretion of GnRH is associated with …

Kisspeptin signaling in the hypothalamus appears critical for the onset of puberty and driving
the reproductive axis. In sheep, reproduction is seasonal, being activated by short days and …

The control of reproductive processes involves the integration of a number of factors from the
internal and external environment, with the final output signal of these processes being the …

There is strong evidence that kisspeptin acts to regulate GnRH secretion, but whether there
is also a component of action on the gonadotropes is not clear. Using quantitative RT-PCR …

The continuous activation of the kisspeptin receptor by its agonists causes the abrogation of
kisspeptin signaling, leading to decreased pulsatile luteinizing hormone (LH) secretion …

We have previously demonstrated that a constant intravenous infusion of kisspeptin (Kp) for
48h in anestrous ewes induces a preovulatory luteinizing hormone (LH) surge followed by …

Kisspeptin is a peptide that has been implicated in the regulation of GnRH cells in the brain.
Immunohistochemical studies were undertaken to examine the distribution of kisspeptin …

Kisspeptin, a regulator of gonadotropin-releasing hormone, has been hypothesized as an
integrator of nutrition and hormones critical to metabolism and the regulation of …

Contents The neuronal control of fertility and sterility has been a subject of research for
years. However, nowadays, in spite of considerable literature about GnRH during the last …