GPR35 is a family A orphan G protein-coupled receptor whose biological functions are
largely unknown. Identification of novel GPR35 ligands is essential to elucidate the biology …

Drugs targeting the orphan receptor GPR35 have potential therapeutic application in a
number of disease areas, including inflammation, metabolic disorders, nociception, and …

GPR35 is a Gi/o-and G16-coupled receptor abundantly expressed in gastrointestinal tissues
and immune cells. Kynurenic acid (a tryptophan metabolite and ionotropic glutamate …

A series of alkylpyrimidine-4, 6-diol derivatives were designed and synthesized as novel
GRP84 agonists based on a high-throughput screening (HTS) hit 1. 6-Nonylpyridine-2, 4 …

GPR35 is an orphan G protein-coupled receptor that is not well-characterized. Here we
employ dynamic mass redistribution (DMR) assays to discover new GPR35 agonists. DMR …

Screening with dynamic mass redistribution (DMR) assays in a native cell line HT-29 led to
identification of two novel series of chemical compounds, 2-(4-methylfuran-2 (5 H)-ylidene) …

GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR) first identified more
than 20 years ago. In the intervening period, identification of strong expression in the lower …

GPR139 is an orphan G protein-coupled receptor (GPCR) that is primarily expressed in the
brain in regions known to regulate motor control and metabolism. Here, we screened a …

GPR27 belongs, with GPR85 and GPR173, to a small subfamily of three receptors called
“Super-Conserved Receptors Expressed in the Brain”(SREB). It has been postulated to …

GPR35 is a G protein-coupled receptor expressed in the immune, gastrointestinal, and
nervous systems in gastric carcinomas and is implicated in heart failure and pain perception …