Vaccination has potential to eliminate infectious diseases. However, parasitic infections
such as helminths may hinder vaccines from providing optimal protection. We reviewed …

Immune responses to vaccination are heterogeneous between individuals; the same
vaccine that provides protection in one circumstance may be ineffective in another. One …

Vaccines are one of the most successful medical inventions to enable the eradication or
control of common and fatal diseases. Environmental exposure of hosts, including helminth …

Helminths contribute a larger global burden of disease than both malaria and tuberculosis.
These eukaryotes have caused human infections since before our earliest recorded history …

Vaccines against human helminths are being developed but the choice of optimal
parasitological endpoints and effect measures to assess their efficacy has received little …

Parasitic helminths infect over one-fourth of the human population resulting in significant
morbidity, and in some cases, death in endemic countries. Despite mass drug administration …

Helminth parasites infect over one fourth of the human population and are highly prevalent
in livestock worldwide. In model systems, parasites are strongly immunomodulatory, but the …

Several important issues must be considered when performing any vaccination in areas with
high prevalence of geohelminths. Immunization of populations infected with geohelminths …

Intestinal helminths infect approximately 2 billion people worldwide. Worm burdens correlate
with disease morbidity and children generally harbor the largest numbers. The majority of …

A wealth of data on the protective immune mechanisms induced following helminth infection
exist, but how antibody responses protect against helminth infections is unclear and shows …