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A New Synthesis of the Alkaloid (5)-Colchicine Page 1 300 JCS CHEM. COMM., 1974 A
New Synthesis of the Alkaloid (5)-Colchicine By EIICHI KOTANI, FUDO MIYAZAKI, and …

A fully regiocontrolled synthesis of the title compound 6, an AC-ring analogue of the alkaloid
colchicine 1, is reported. The key step associated with the sequence used was condensation …

If the foregoing ideas are broadly correct, activity from [2-14C] tyrosine should be
concentrated largely at position 6 of colchicine, and a degradation of the alkaloid was …

A review, covering: structures and medicinal uses of these alkaloids (mainly of colchicine
and colchamine); raw materials containing them in adequate quantities (seeds of Colchicum …

Publisher Summary This chapter discusses the colchicine and related compounds. Although
Colchicum has been known since the days of the early Egyptians and Greeks and the …

The tetracyclic compound 3a, which has been synthesised in nine steps from the known
cyclohexenone 6, reacts with 1, 8-diazabicyclo [5.4. 0] undec-7-ene (DBU) to give …

Experiments with 14C-and 3H-labelled compounds in Colchicum byzantinum and C.
autumnale show that in the early stages of biosynthesis the major pathway to colchicine (7) …

With the dual object of synthesising a colchicine degradation product and thus establishing
its structure, and of obtaining analogous compounds for biological study, possible synthetic …

Tetrahedron Letters,Vol.27,No.9,pp 1099-1102,1986 0040-4039/86 $3.00 + .OO Printed in
Great Britain 81986 Pergamon Press Ltd. TH Page 1 Tetrahedron Letters,Vol.27,No.9,pp …