[HTML][HTML] Identifying drug targets in pancreatic ductal adenocarcinoma through machine learning, analyzing biomolecular networks, and structural modeling

W Yan, X Liu, Y Wang, S Han, F Wang, X Liu… - Frontiers in …, 2020 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related
death and has an extremely poor prognosis. Thus, identifying new disease-associated …

[HTML][HTML] Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis

Y Tang, Z Zhang, Y Tang, X Chen… - Oncology …, 2018 - spandidos-publications.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most complicated and fatally
pathogenic human malignancies. Therefore, there is an urgent need to improve our …

Identification of key pathways and candidate genes in pancreatic ductal adenocarcinoma using bioinformatics analysis

Y He, Y Liu, J Gong, C Liu, H Zhang… - Oncology …, 2019 - spandidos-publications.com
Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a high degree of
malignancy that is difficult to diagnose and treat. The present study integrated PDAC cohort …

Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma

Y Xiao, B Zhang, JM Cloyd, G Xu, S Du, Y Mao… - Surgical Oncology, 2022 - Elsevier
Introduction The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is
highly variable and there is a paucity of effective treatment options for patients with PDAC …

Analysis of dynamic molecular networks for pancreatic ductal adenocarcinoma progression

Z Pan, L Li, Q Fang, Y Zhang, X Hu, Y Qian… - Cancer cell …, 2018 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors.
The rapid progression of PDAC results in an advanced stage of patients when diagnosed …

PDAC-ANN: an artificial neural network to predict pancreatic ductal adenocarcinoma based on gene expression

PP Almeida, CP Cardoso, LM de Freitas - BMC cancer, 2020 - Springer
Background Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality
and metastatic potential, there is a lack of effective therapies and a low survival rate for this …

Identification of key regulators of pancreatic ductal adenocarcinoma using bioinformatics analysis of microarray data

N Li, X Zhao, S You - Medicine, 2019 - journals.lww.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer, and its
etiology remains largely unknown. This study aimed to screen a panel of key genes and to …

[PDF][PDF] Screening and validating the core biomarkers in patients with pancreatic ductal adenocarcinoma

Y Li, YY Zhu, GP Dai, DJ Wu, ZZ Gao, L Zhang… - Math Biosci …, 2019 - aimspress.com
Pancreatic ductal adenocarcinoma (PAAD) is one of the most common malignant tumors in
digestive system. To find the new therapeutic targets and explore potential mechanisms …

Weighted gene co-expression network analysis reveals key genes involved in pancreatic ductal adenocarcinoma development

M Giulietti, G Occhipinti, G Principato, F Piva - Cellular Oncology, 2016 - Springer
Purpose Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy. Up
till now, the patient's prognosis remains poor which, among others, is due to the paucity of …

Identification of genes and pathways associated with pancreatic ductal adenocarcinoma by bioinformatics analyses

J Long, Z Zhang, Z Liu, Y Xu, C Ge - Oncology letters, 2016 - spandidos-publications.com
This study aimed to explore the underlying genes and pathways associated with pancreatic
ductal adenocarcinoma (PDAC) by bioinformatics analyses. Gene expression profile …