An All‐in‐One Nano‐Biomimetic Polyamidoamine Dendrimer Platform for Treatment of CRKP Pneumonia
S Duan, H Li, F Wang, L Li, H Fan, Y Ma… - Advanced Functional …, 2024 - Wiley Online Library
Polymyxin B (PMB) is often considered as the last line of defense for treating carbapenem‐
resistant Klebsiella pneumoniae (CRKP). However, its efficacy is hindered by limited …
resistant Klebsiella pneumoniae (CRKP). However, its efficacy is hindered by limited …
An inflammation-targeted nanoparticle with bacteria forced release of polymyxin B for pneumonia therapy
P Zhang, Q Ouyang, T Zhai, J Sun, J Wu, F Qin… - Nanoscale, 2022 - pubs.rsc.org
The epidemic of multidrug-resistant Gram-negative bacteria is an ever-growing global
concern. Polymyxin B (PMB), a kind of “old fashioned” antibiotic, has been revived in clinical …
concern. Polymyxin B (PMB), a kind of “old fashioned” antibiotic, has been revived in clinical …
[HTML][HTML] High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy
D Cheng, R Tian, T Pan, Q Yu, L Wei, J Liyin, Y Dai… - Bioactive materials, 2024 - Elsevier
Polymyxins are the last line of defense against multidrug-resistant (MDR) Gram-negative
bacterial infections. However, this last resort has been threatened by the emergence of …
bacterial infections. However, this last resort has been threatened by the emergence of …
A potent and selective antimicrobial poly (amidoamine) dendrimer conjugate with LED209 targeting QseC receptor to inhibit the virulence genes of gram negative …
XY Xue, XG Mao, Z Li, Z Chen, Y Zhou, Z Hou… - … , Biology and Medicine, 2015 - Elsevier
The pandemic of multidrug-resistant Gram negative bacteria (GNB) is a worldwide
healthcare concern, and very few antibiotics are being explored to match the clinical …
healthcare concern, and very few antibiotics are being explored to match the clinical …
Infection‐responsive polysaccharide‐based drug‐loaded nano‐assembly for dual‐modal treatment against drug‐resistant bacterial lung infection
L Han, Z Yuan, HM Ren, W Song, R Wu, J Li, Z Guo… - …, 2024 - Wiley Online Library
The escalating issue of lung infections induced by multi‐drug resistant (MDR) bacteria is
threatening human health. Thus, the development of efficient drug delivery systems is …
threatening human health. Thus, the development of efficient drug delivery systems is …
Co-delivery of azithromycin and ibuprofen by ROS-responsive polymer nanoparticles synergistically attenuates the acute lung injury
W Muhammad, Y Zhang, J Zhu, J Xie, S Wang… - Biomaterials …, 2023 - Elsevier
Bacterial infection causes lung inflammation and recruitment of several inflammatory factors
that may result in acute lung injury (ALI). During bacterial infection, reactive oxygen species …
that may result in acute lung injury (ALI). During bacterial infection, reactive oxygen species …
Amphiphilic Dendrimer as Potent Antibacterial against Drug-Resistant Bacteria in Mouse Models of Human Infectious Diseases
Modern medicine continues to struggle against antibiotic-resistant bacterial pathogens.
Among the pathogens of critical concerns are the multidrug-resistant (MDR) Pseudomonas …
Among the pathogens of critical concerns are the multidrug-resistant (MDR) Pseudomonas …
[HTML][HTML] Polymyxin B stabilized DNA micelles for sustained antibacterial and antibiofilm activity against P. aeruginosa
A Sousa, V Borøy, A Bæverud, K Julin… - Journal of Materials …, 2023 - pubs.rsc.org
Nucleic acid-based materials showcase an increasing potential for antimicrobial drug
delivery. Although numerous reports on drug-loaded DNA nanoparticles outline their pivotal …
delivery. Although numerous reports on drug-loaded DNA nanoparticles outline their pivotal …
Size and charge adaptive clustered nanoparticles targeting the biofilm microenvironment for chronic lung infection management
Chronic lung infection caused by bacterial biofilms is an extremely serious clinical problem,
which can lead to the failure of antibiotic therapy. Although nanoparticles have shown great …
which can lead to the failure of antibiotic therapy. Although nanoparticles have shown great …
[HTML][HTML] Polycationic phosphorous dendrimer potentiates multiple antibiotics against drug-resistant mycobacterial pathogens
Mycobacterium tuberculosis (Mtb), causative agent of tuberculosis (TB) and non-tubercular
mycobacterial (NTM) pathogens such as Mycobacterium abscessus are one of the most …
mycobacterial (NTM) pathogens such as Mycobacterium abscessus are one of the most …