An All‐in‐One Nano‐Biomimetic Polyamidoamine Dendrimer Platform for Treatment of CRKP Pneumonia

S Duan, H Li, F Wang, L Li, H Fan, Y Ma… - Advanced Functional …, 2024 - Wiley Online Library
Polymyxin B (PMB) is often considered as the last line of defense for treating carbapenem‐
resistant Klebsiella pneumoniae (CRKP). However, its efficacy is hindered by limited …

An inflammation-targeted nanoparticle with bacteria forced release of polymyxin B for pneumonia therapy

P Zhang, Q Ouyang, T Zhai, J Sun, J Wu, F Qin… - Nanoscale, 2022 - pubs.rsc.org
The epidemic of multidrug-resistant Gram-negative bacteria is an ever-growing global
concern. Polymyxin B (PMB), a kind of “old fashioned” antibiotic, has been revived in clinical …

[HTML][HTML] High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy

D Cheng, R Tian, T Pan, Q Yu, L Wei, J Liyin, Y Dai… - Bioactive materials, 2024 - Elsevier
Polymyxins are the last line of defense against multidrug-resistant (MDR) Gram-negative
bacterial infections. However, this last resort has been threatened by the emergence of …

A potent and selective antimicrobial poly (amidoamine) dendrimer conjugate with LED209 targeting QseC receptor to inhibit the virulence genes of gram negative …

XY Xue, XG Mao, Z Li, Z Chen, Y Zhou, Z Hou… - … , Biology and Medicine, 2015 - Elsevier
The pandemic of multidrug-resistant Gram negative bacteria (GNB) is a worldwide
healthcare concern, and very few antibiotics are being explored to match the clinical …

Infection‐responsive polysaccharide‐based drug‐loaded nano‐assembly for dual‐modal treatment against drug‐resistant bacterial lung infection

L Han, Z Yuan, HM Ren, W Song, R Wu, J Li, Z Guo… - …, 2024 - Wiley Online Library
The escalating issue of lung infections induced by multi‐drug resistant (MDR) bacteria is
threatening human health. Thus, the development of efficient drug delivery systems is …

Co-delivery of azithromycin and ibuprofen by ROS-responsive polymer nanoparticles synergistically attenuates the acute lung injury

W Muhammad, Y Zhang, J Zhu, J Xie, S Wang… - Biomaterials …, 2023 - Elsevier
Bacterial infection causes lung inflammation and recruitment of several inflammatory factors
that may result in acute lung injury (ALI). During bacterial infection, reactive oxygen species …

Amphiphilic Dendrimer as Potent Antibacterial against Drug-Resistant Bacteria in Mouse Models of Human Infectious Diseases

N King, D Dhumal, SQ Lew, SH Kuo… - ACS Infectious …, 2024 - ACS Publications
Modern medicine continues to struggle against antibiotic-resistant bacterial pathogens.
Among the pathogens of critical concerns are the multidrug-resistant (MDR) Pseudomonas …

[HTML][HTML] Polymyxin B stabilized DNA micelles for sustained antibacterial and antibiofilm activity against P. aeruginosa

A Sousa, V Borøy, A Bæverud, K Julin… - Journal of Materials …, 2023 - pubs.rsc.org
Nucleic acid-based materials showcase an increasing potential for antimicrobial drug
delivery. Although numerous reports on drug-loaded DNA nanoparticles outline their pivotal …

Size and charge adaptive clustered nanoparticles targeting the biofilm microenvironment for chronic lung infection management

Y Gao, J Wang, M Chai, X Li, Y Deng, Q Jin, J Ji - ACS nano, 2020 - ACS Publications
Chronic lung infection caused by bacterial biofilms is an extremely serious clinical problem,
which can lead to the failure of antibiotic therapy. Although nanoparticles have shown great …

[HTML][HTML] Polycationic phosphorous dendrimer potentiates multiple antibiotics against drug-resistant mycobacterial pathogens

M Imran, S Singh, MN Ahmad, P Malik… - Biomedicine & …, 2024 - Elsevier
Mycobacterium tuberculosis (Mtb), causative agent of tuberculosis (TB) and non-tubercular
mycobacterial (NTM) pathogens such as Mycobacterium abscessus are one of the most …