Effect of isoorientin on intracellular antioxidant defence mechanisms in hepatoma and liver cell lines

L Yuan, J Wang, W Wu, Q Liu, X Liu - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Isoorientin (ISO) is considered one of the most important flavonoid-like compounds
responsible for health benefits, including the prevention of liver damage as well as …

Isoorientin protects BRL-3A rat liver cell against hydrogen peroxide-induced apoptosis by inhibiting mitochondrial dysfunction, inactivating MAPKs, activating Akt and …

L Yuan, X Ren, Y Wu, J Wang, H Xiao, X Liu - Biomedicine & Aging …, 2013 - Elsevier
Isoorientin (ISO) is a flavonoid compound, and possesses a significant antioxidant potential.
However, the effects of ISO on the oxidative damage in normal hepatocytes remain …

Isoorientin induces Nrf2 pathway-driven antioxidant response through phosphatidylinositol 3-kinase signaling

JH Lim, HS Park, JK Choi, IS Lee, HJ Choi - Archives of pharmacal …, 2007 - Springer
Because oxidative stress is involved in the pathogenesis of various chronic diseases and
the aging process, antioxidants that can increase the intrinsic antioxidant potency are …

Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells

L Yuan, J Wang, H Xiao, C Xiao, Y Wang… - Toxicology and applied …, 2012 - Elsevier
Isoorientin (ISO) is a flavonoid compound that can be extracted from several plant species,
such as Phyllostachys pubescens, Patrinia, and Drosophyllum lusitanicum; however, its …

[HTML][HTML] Metabolomic study on the protective effect of isoorientin against myocardial infarction

S Huang, Z Li, S Jiang, M Xu - Biochemical and Biophysical Research …, 2022 - Elsevier
Myocardial infarction has become one of the largest threats to human life. Myocardial
ischemia and hypoxia caused by myocardial infarction are important causes of myocardial …

Protective effect of isoorientin on oleic acid-induced oxidative damage and steatosis in rat liver cells

T Luo, S Jiang, B Zhou, Q Song, J Du, P Liu… - Frontiers in …, 2022 - frontiersin.org
The harm of nonalcoholic fatty liver disease to human health is increasing, which calls for
urgent prevention and treatment of the disease. Isoorientin is an effective ingredient of …

Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β

X Fan, H Lv, L Wang, X Deng, X Ci - Frontiers in pharmacology, 2018 - frontiersin.org
Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …

Isoorientin attenuated the pyroptotic hepatocyte damage induced by benzo [a] pyrene via ROS/NF-κB/NLRP3/Caspase-1 signaling pathway

H Li, L Yuan, X Li, Y Luo, Z Zhang, J Li - Antioxidants, 2021 - mdpi.com
Isoorientin (Iso), a natural bioactive flavonoid, possesses significant anti-tumor and anti-
oxidant activities. Benzo [a] pyrene (BaP) is a food processing injurant with carcinogenicity …

Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS-regulated MAPK, STAT3 and NF-κB signaling pathways

WT Xu, GN Shen, TZ Li, Y Zhang… - International …, 2020 - spandidos-publications.com
Isoorientin (ISO) is a naturally occurring C-glycosyl flavone that has various pharmacological
properties, such as anti-bacterial and anti-inflammatory effects. However, its underlying …

A mechanism of isoorientin-induced apoptosis and migration inhibition in gastric cancer AGS cells

T Zhang, YH Xiu, H Xue, YN Li, JL Cao, WS Hou, J Liu… - Pharmaceuticals, 2022 - mdpi.com
Isoorientin (ISO) is a flavonoid compound containing a luteolin structure, which can induce
autophagy in some tumor cells. This study investigated the impact of ISO in gastric cancer …