[HTML][HTML] Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl]-N-arylacetamides: An …
Diabetes mellitus (DM) is a chronic disorder and has affected a large number of people
worldwide. Insufficient insulin production causes an increase in blood glucose level that …
worldwide. Insufficient insulin production causes an increase in blood glucose level that …
Exploring of novel 4-hydroxy-2H-benzo [e][1, 2] thiazine-3-carbohydrazide 1, 1-dioxide derivative as a dual inhibitor of α-glucosidase and α-amylase: Molecular …
Diabetes mellitus (DM) is a metabolic disorder that leads to hyperglycemia due to improper
insulin secretion. The study aims to investigate the anti-diabetic potential of benzothiazine …
insulin secretion. The study aims to investigate the anti-diabetic potential of benzothiazine …
[PDF][PDF] Synthesis of new bis (dimethylamino) benzophenone hydrazone for diabetic management: In-vitro and in-silico approach
Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic
individuals. Bis (dimethylamino) benzophenone derivatives 1–27 were synthesized from bis …
individuals. Bis (dimethylamino) benzophenone derivatives 1–27 were synthesized from bis …
Design, synthesis, and in silico studies of benzimidazole bearing phenoxyacetamide derivatives as α-glucosidase and α-amylase inhibitors
N Shayegan, A Iraji, N Bakhshi, A Moazzam… - Journal of Molecular …, 2022 - Elsevier
Benzimidazole bearing phenoxyacetamide derivatives 7a-l were designed and synthesized
as anti-diabetic agents. All derivatives were evaluated for in vitro α-glucosidase and α …
as anti-diabetic agents. All derivatives were evaluated for in vitro α-glucosidase and α …
Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2, 5-dione and thiazolidine-2, 4-dione …
Abstract α-Glucosidase is considered as a therapeutic target for the treatment of type 2
diabetes mellitus (DM2). In current study, we synthesized pyrrolidine-2, 5-dione …
diabetes mellitus (DM2). In current study, we synthesized pyrrolidine-2, 5-dione …
Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: in silico studies and SAR predictions
A new series of quinoline derivatives 6–30 was identified as potent α-glucosidase inhibitors.
These analogs exhibited inhibitory potentials (IC50 values) in the ranges between 2.60 and …
These analogs exhibited inhibitory potentials (IC50 values) in the ranges between 2.60 and …
Synthesis of Novel 2,3-Dihydro-1,5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies
R Mehmood, EU Mughal, EB Elkaeed, RJ Obaid… - ACS …, 2022 - ACS Publications
In the present study, a series of 2, 3-dihydro-1, 5-benzothiazepine derivatives 1B–14B has
been synthesized sand characterized by various spectroscopic techniques. The enzyme …
been synthesized sand characterized by various spectroscopic techniques. The enzyme …
Synthesis, α-glucosidase and α-amylase inhibitory activities, acute toxicity and molecular docking studies of thiazolidine-2, 4-diones derivatives
In the present study, a series of thiazolidine-2, 4-diones derivatives (3a–3e) and (4a–4e)
were synthesized and characterized by 1H NMR, 13C NMR and ESI-MS spectrometry. All …
were synthesized and characterized by 1H NMR, 13C NMR and ESI-MS spectrometry. All …
Synthesis, molecular modeling and biological evaluation of 5-arylidene-N, N-diethylthiobarbiturates as potential α-glucosidase inhibitors
Background: Barbituric acid derivatives are a versatile group of compounds which are
identified as potential pharmacophores for the treatment of anxiety, epilepsy and other …
identified as potential pharmacophores for the treatment of anxiety, epilepsy and other …
Synthesis, in-vitro α-glucosidase inhibition and molecular docking studies of 1, 3, 4-thiadiazole-5, 6-diphenyl-1, 2, 4-triazine hybrids: Potential leads in the search of …
H Kumar, M Dhameja, S Kurella, A Uma… - Journal of Molecular …, 2023 - Elsevier
Abstract A series of 1, 3, 4-thiadiazole-5, 6-diphenyl-triazine hybrids 7a-l have been
designed, synthesized and investigated for the α-glucosidase inhibitory activities. All the …
designed, synthesized and investigated for the α-glucosidase inhibitory activities. All the …