Despite 100years of research since the seminal work of Angelo Mosso (1846–1910), our
understanding of the interactions between the nervous system and muscle during the …

Physiological Analysis of Skeletal Muscle Weakness and Fatigue Page 1 Clinical Science and
Molecular Medicine (1978), 54,463-470 EDITORIAL REVIEW Physiological analysis of skeletal …

Muscle fatigue has been defined as a temporary loss in force or torque-generating ability
due to recent muscle contraction. 1 The mechanisms underlying muscle fatigue are …

The force produced by muscles declines during prolonged activity and this decline arises
largely from processes within the muscle. At a cellular level the reduced force could be …

Fatigue is a common experience of individuals suffering from chronic illnesses. Mechanisms
responsible for fatigue may be central or peripheral. Central fatigue may result from proximal …

The study of human fatigue stretches back centuries and remains a significant part of
medical and social discourse. In the exercise sciences fatigue is routinely related to the …

Skeletal muscle comprises the largest organ system in the human body and is essential for
force generation and movement. Skeletal muscle is subjected to considerable stresses …

PURPOSE: To identify the role of fatigue, its evaluation and its causes in the
pathophysiology context of acquired or hereditary neuromuscular diseases of the spinal …

Highlights•The reliance on anaerobic metabolism causes fatigue during high-intensity
exercise.•Metabolic pathways maintain ATP at levels that do not impair contractile …

The manifestations of fatigue, as observed by reductions in the ability to produce a given
force or power, are readily apparent soon after the initiation of intense activity. Moreover …