The term fatigue is used to describe a distressing and persistent symptom of physical and/or
mental tiredness in certain clinical populations, with distinct but ultimately complex …

The results of recent studies indicate that in healthy men and women aged beyond
approximately 65 years, the energy-producing pathways in skeletal muscle may combine …

Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including
exercise, injury, disuse, and, as discussed here, aging. Humans achieve peak skeletal …

A limited number of studies have investigated the effect of old age on neuromuscular fatigue,
yet a variety of protocols have been used to compare the fatigability of old and young …

This is a discussion primarily about the cellular mechanisms of muscle fatigue. I will begin
with a definition that muscle fatigue is a decrease in the peak tension and power output …

Slowing of the contractile properties of skeletal muscle is one of the characteristic features of
fatigue. First studied as a slowing of relaxation from an isometric contraction, it has become …

The cause of muscle fatigue has been studied for more than 100 yr, yet its molecular basis
remains poorly understood. Prevailing theories suggest that much of the fatigue-induced …

Skeletal muscle is a highly plastic tissue. For example, muscle hypertrophies during strength
training and increases its oxidative capacity in response to endurance training. Conditions …

Fatigue is the decrease in active force that happens after repeated muscle stimulation, and
post tetanic twitch potentiation (PTP) is the increase in twitch force observed after repeated …

The study of fatigue and the factors that limit, or regulate, exercise performance has
captivated scientists for centuries, but a thorough explanation of the etiology of this condition …