What is known and objective Timely and appropriate dosing of antibiotics is essential for the
treatment of bacterial sepsis. Critically ill patients treated with continuous kidney …

Objectives To evaluate the pharmacokinetics of piperacillin/tazobactam in critically ill
patients undergoing continuous renal replacement therapy (CRRT) and to assess the …

Critically ill patients undergo significant pathophysiological changes that affect antibiotic
pharmacokinetics. Piperacillin/tazobactam administered by continuous infusion (CI) …

Study Objective To evaluate the pharmacokinetic and pharmacodynamic profiles of
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …

This prospective pharmacokinetic study aimed to compare the clearance of piperacillin-
tazobactam administered as a 24-h continuous infusion between continuous venovenous …

Abstract Background and Objectives Although dose optimization studies have been
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …

Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …

The percentage of the time that the free drug concentration remains above a concentration
threshold (% fT> concentration threshold) has frequently been identified to be the optimal …

Purpose To determine whether augmented renal clearance (ARC) impacts negatively on
piperacillin-tazobactam unbound concentrations in critically ill patients receiving 16 g/2 …

Background Tazobactam/piperacillin (TAZ/PIPC), which is often combined with continuous
renal replacement therapy (CRRT), induces renal excretion and is thought to have a high …