Early observations showed a lack of growth control and terminal differentiation with a lack of
gap junctional intercellular communication (GJIC). Subsequent observations showed that …

Understanding the process of carcinogenesis will involve both the accumulation of many
scientific facts derived from molecular, biochemical, cellular, physiological, whole animal …

Since carcinogenesis is a multi-stage, multi-mechanism process, involving mutagenic, cell
death and epigenetic mechanisms, during the “initiation/promotion/and progression” …

In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

Hanahan and Weinberg (2000, Cell 100: 57‐70) listed “hallmarks” of cancer that must be
considered in order to understand the underlying determinants of carcinogenesis:(a) self …

The development of many forms of intercellular communication was essential for the
evolution of multicellular organisms. The organization of cells into tissues and organs and …

Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

Cells within a tissue continuously interact to coordinate normal tissue functions and maintain
homeostasis. Gap junctional communication (GJC), mediated by the connexin protein family …

The 'cancer stem cell'hypothesis has pointed to a specific target for new cancer therapies.
The hypothesis is based on the observation that only the 'cancer stem cell'among the other …