Advances in understanding the neurobiology of addiction indicate that not only
dopaminergic neurotransmissions but also glutamatergic neurotransmissions within the …

Although some studies report increased responsiveness of nucleus accumbens (NAc)
AMPA receptors (AMPARs) after withdrawal from repeated cocaine treatment, others report …

Plasticity of glutamate transmission in neuronal circuits involving the nucleus accumbens
(NAc) is now recognized to play a critical role in cocaine addiction. NAc neurons are excited …

Nucleus accumbens (NAc) neurons are excited primarily by AMPA-type glutamate receptors
(AMPAR). This is required for cocaine seeking in animal models of cocaine addiction …

Regulation of AMPA receptor trafficking is important for many forms of neuronal plasticity. In
this study, a protein cross-linking assay was used to evaluate the contribution of AMPA …

Abstract Changes in α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptor
(AMPAR) surface expression in the rodent nucleus accumbens (NAc) are produced by …

Background The development and persistence of addiction is mediated in part by drug-
induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors …

Drugs of abuse induce long-lasting changes in neural circuits that may underlie core
components of addiction. Here we focus on glutamatergic synapses onto dopamine (DA) …

Cocaine-induced plasticity of mesocorticolimbic dopamine (DA) neurons, originating in the
ventral tegmental area (VTA), persists in the absence of cocaine and may contribute to both …

Repeated exposure to psychostimulant drugs such as cocaine or amphetamine can promote
drug-seeking and-taking behavior. In rodent addiction models, persistent changes in …