There is increasing evidence that noncollagenous matrix proteins initiate bone
mineralization in vivo. Fibronectin, which is present during the early phases of …

The effect of bone matrix protein of osteonectin on de novo formation of apatite was studied
in a wide range of calcium phosphate solutions in the presence of collagen. In every …

One of our goals is to understand the mechanisms that deposit mineral within collagen
fibrils, and as a first step we recently determined the size exclusion characteristics of the …

Four major non-collagenous bone proteins were localised by single and double immuno-
histochemistry during de novo mineralisation and bone resorption. Both osteopontin and …

The biosynthesis of fibronectin during the in vivo development of matrix-induced
endochondral bone was investigated by using [35S] methionine in rats. The dmineralized …

This study investigate the biochemical structure of proteoglycans synthesized during matrix
maturation by mineralizing bone cells in vitro, in the presence and absence of fluoride. Bone …

The mineral in bone is located primarily within the collagen fibril, and during mineralization
the fibril is formed first and then water within the fibril is replaced with mineral. Our goal is to …

The role of adhesion molecules like osteopontin and bone sialoprotein, both containing the
Arg‐Gly‐Asp sequence have been shown to have a role in mineral formation, whereas …

While the exact mechanisms regulating bone homeostasis are unknown, it is generally
accepted that factors with the capacity to regulate cell attachment and spreading play a role …

Noncollagenous phosphoproteins that interact with type I collagen are thought to nucleate
the mineral phase to collagen network of mineralized tissues. Previously, we found that …