Type 2 diabetes results from the development of insulin resistance and a concomitant
impairment of insulin secretion. Mitochondrial dysfunctions are thought to be the major …

Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia
due to absolute or relative lack of insulin. Though great efforts have been made to …

Mitochondria play a key role as major regulators of cellular energy homeostasis, but in the
context of mitochondrial dysfunction, mitochondria may generate reactive oxidative species …

Mitochondrial dysfunction is discussed as a key player in the pathogenesis of type 2
diabetes mellitus (T2Dm), a highly prevalent disease rapidly developing as one of the …

Mitochondrial dysfunction in muscle has been implicated to play a causative role or being an
indirect consequence of insulin resistance in type-2 diabetes. In order to investigate …

Mitochondria play important roles in cellular physiology and in various pathologies. Over the
last decade, great achievements have been made in study of the whole mitochondrial …

It has been proposed that mitochondrial dysfunction is involved in the pathogenesis of type 2
diabetes (T2D). To dissect the underlying mechanisms, we performed a multiplexed …

Mitochondrial dysfunction has emerged as a central pathomechanism in the setting of
obesity and diabetes mellitus, linking these intertwined pathologies that share insulin …

Background The prevalence of type 2 diabetes is rapidly increasing world-wide and insulin
resistance is central to the aetiology of this disease. The biology underpinning the …

Introduction Data suggest malfunctioning mitochondria reduce oxidation and adenosine
triphosphate (ATP) production, disrupting insulin signalling. Cytochrome c (CC) …