In the tumor cells exposed to hypoxia, hypoxia-inducible factor-1 (HIF-1)-mediated
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …

Hypovasculature is an outstanding characteristic of pancreatic cancers in imaging
diagnosis, suggesting that blood supply is poor in pancreatic cancer tissues. Despite poor …

Intratumoral hypoxia and paracrine insulin stimulate the expression of hypoxia inducible
factor-1α (HIF-1α) in pancreatic cancer cells. In the present studies, we investigated whether …

Aims To determine whether hypoxia-inducible factor 1 (HIF-1) is specifically activated by
hypoxia in vitro in pancreatic cancer cells and correlated these findings with tumor …

Purpose: Pancreatic cancer is characterized by intratumoral hypoxia, early and aggressive
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …

Pancreatic cancer patients frequently show hyperglycemia, but it is uncertain whether
hyperglycemia stimulates pancreatic cancer cells. We have investigated whether excess …

Aims: The transcription factor hypoxia‐inducible factor‐1α (HIF‐1α) plays a key role in the
cellular adaptation to hypoxia and the activation of several genes that have been implicated …

Hypoxia and the acquisition of a glycolytic phenotype are intrinsic features of the tumor
microenvironment. The hypoxia inducible factor-1α (HIF-1α) pathway is activated under …

Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …

Background Hypoxia is a common feature of rapidly growing solid tumors. Therefore,
cellular adaptation to hypoxia and altered glucose metabolism are fundamental to the …