Hepatitis B virus (HBV) superinfection in chronic hepatitis C represents a natural model to
investigate whether or not hepatitis C virus (HCV) can influence priming and maturation of …

Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes
by HBV-specific CD8 cells has been assumed to be the central mechanism causing both …

Background Hepatitis C virus (HCV) persistence is associated with impaired CD8 functions.
Whether functional restoration of CD8 T cells chronically exposed to antigen can be …

Chronic hepatitis C virus (HCV) infection is associated with impaired proliferative, cytokine,
and cytotoxic effector functions of HCV-specific CD8+ T cells that probably contribute …

To characterize acute‐phase hepatitis B virus (HBV)‐specific T cell responses associated
with self‐limited and persistent HBV infections, we compared a patient with acute HBV/HCV …

We investigated the proliferative response and IL-2 receptor (IL-2R) expression in peripheral
blood mononuclear cells (PBMC) activated with anti-CD3 mAb alone or in combination with …

Highlights•HCV-specific T cells are essential for protective immunity to HCV and disease
progression.•During persistent infection, HCV-specific T cells are functionally impaired.•T …

Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV)
infection. The mechanism of HCV‐related lymphoproliferative disorders is not fully …

Hepatitis C virus (HCV) has a propensity to establish chronic infection that is characterized
by attenuated virus-specific T-cell responses. Mechanisms leading to T-cell attenuation are …

Background/Aims: Specific T cell responses during acute hepatitis B and during chronic
hepatitis C have been described in detail. However, the T cell responses during the rare …