Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder and is characterized by the formation of cellular inclusions inside neurons that are …

Parkinson's disease is characterized by accumulation of α-synuclein (αSyn). Release of
oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via …

Synucleinopathies such as Parkinson's disease (PD) are hallmarked by α‐synuclein (α‐syn)
pathology and neuroinflammation. This neuroinflammation involves activated microglia with …

According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …

Abstract Background α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease
(PD), has been recognized to induce the production of interleukin-1β in a process that …

Parkinson's disease (PD) is the second most common neurodegenerative disease, with two
main pathological features: misfolded α-synuclein protein accumulation and …

Persistent microglia-mediated neuroinflammation is a major pathophysiological contributor
to the progression of Parkinson's disease (PD), but the cell-signaling mechanisms governing …

Parkinson's disease (PD) is an age-related movement disorder characterized by a
progressive degeneration of dopaminergic neurons in the midbrain. Although the presence …

Background Parkinson's disease (PD) is characterized by the loss of nigral dopaminergic
neurons leading to impaired striatal dopamine signaling, α-synuclein-(α-syn-) rich …

Synucleinopathies are age-related neurological disorders characterized by the progressive
deposition of α-synuclein (α-syn) aggregates and include Parkinson's disease (PD) and …