Parkinson's disease (PD) is one of the most common neurodegenerative diseases. It is
characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of …

Two key pathological hallmarks of neurodegenerative diseases, including Alzheimer's
disease (AD) and Parkinson's disease (PD), are the accumulation of misfolded protein …

Background Synucleinopathies of the aging population are an heterogeneous group of
neurological disorders that includes Parkinson's disease (PD) and dementia with Lewy …

Microglia are the CNS resident immune cells that react to misfolded proteins through pattern
recognition receptor ligation and activation of inflammatory pathways. Here, we studied how …

Autophagy clears protein aggregates, damaged cellular organelles, and pathogens through
the lysosome. Although autophagy is highly conserved across all cell types, its activity in …

Parkinson's disease (PD) is a neurodegenerative disorder closely related to immunity. An
important aspect of the pathogenesis of PD is the interaction between α-synuclein and a …

To investigate whether different forms of α-synuclein (α-syn) proteins can induce
inflammation and activate the NLRP3 inflammasome, we stimulated with monomeric or …

Pathways to control the spreading of α-synuclein (α-syn) and associated neuropathology in
Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder
worldwide, with a greater prevalence in men than women. The etiology of PD is largely …

Microglial inflammatory neuroregulatory activities affect the tempo of nigrostriatal
degeneration during Parkinson's disease (PD). Such activities are induced, in part, by …