The role of MAPK and dopaminergic synapse signaling pathways in antidepressant effect of electroacupuncture pretreatment in chronic restraint stress rats

X Yang, Z Guo, J Lu, B Zhao, Y Fei, J Li… - Evidence‐Based …, 2017 - Wiley Online Library
Acupuncture has demonstrated the function in ameliorating depressive‐like behaviors via
modulating PKA/CREB signaling pathway. To further confirm the antidepressant mechanism …

Electroacupuncture Reverses CUMS‐Induced Depression‐Like Behaviors and LTP Impairment in Hippocampus by Downregulating NR2B and CaMK II Expression

S Jiang, Z Shen, W Xu - Evidence‐Based Complementary and …, 2021 - Wiley Online Library
Objective. Depression is a global mental health problem with high disability rate, which
brings a huge disease burden to the world. Electroacupuncture (EA) has been shown to be …

Antidepressant effect of electroacupuncture on modulating the expression of c‐Fos/AP‐1 through the JNK signaling pathway

X Li, SM Qi, Y Wang, HW Jiang, YH Li… - The Anatomical …, 2021 - Wiley Online Library
The effectiveness and safety of electroacupuncture (EA) for depression have been identified
by abundant clinical trials and experimental findings. The c‐Jun‐NH (2)‐terminal kinase …

Effects of electroacupuncture on chronic unpredictable mild stress rats depression‐like behavior and expression of p‐ERK/ERK and p‐P38/P38

J Xu, Y She, N Su, R Zhang, L Lao… - … and Alternative Medicine, 2015 - Wiley Online Library
We investigate the antidepressant‐like effect and mechanism of electroacupuncture (EA) on
a chronic unpredictable mild stress rats depression‐like behavior. In our study, depression …

[HTML][HTML] Antidepressant-like effects of acupuncture involved the ERK signaling pathway in rats

X Zhang, Y Song, T Bao, M Yu, M Xu, Y Guo… - … and Alternative Medicine, 2016 - Springer
Background The extracellular signal-regulated kinase (ERK) signaling pathway is
considered to be associated with the pathogenesis and treatment of depression …

Role of AC‐cAMP‐PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats

J Liu, Z Wu, J Sun, L Jiang, S Jiang… - … and Alternative Medicine, 2012 - Wiley Online Library
Adenylyl cyclase (AC)‐cyclic adenosine monophosphate (cAMP)‐cAMP‐dependent protein
kinase A (PKA) cascade is considered to be associated with the pathogenesis and treatment …

The Alterations of IL‐1Beta, IL‐6, and TGF‐Beta Levels in Hippocampal CA3 Region of Chronic Restraint Stress Rats after Electroacupuncture (EA) Pretreatment

T Guo, Z Guo, X Yang, L Sun, S Wang… - Evidence‐Based …, 2014 - Wiley Online Library
Immunological reactions induced by proinflammatory cytokines have been involved in the
pathogenesis of depressive disorders. Recent studies showed that Electroacupuncture (EA) …

Electroacupuncture regulate hypothalamic–pituitary–adrenal axis and enhance hippocampal serotonin system in a rat model of depression

J Le, T Yi, L Qi, J Li, L Shao, JC Dong - Neuroscience letters, 2016 - Elsevier
Abstract Hypothalamic–pituitary–adrenal (HPA) axis has been implicated in the
pathogenesis of depression. Dysfunction of the hippocampal serotonin (5 …

Electroacupuncture prevents the depression-like behavior by inhibiting the NF-κB/NLRP3 inflammatory pathway in hippocampus of mice subjected to chronic mild …

Q Wang, H Bi, H Huang, Y Wang, L Gong, N Qi… - …, 2022 - karger.com
Background: The precise physiological mechanisms of acupuncture in the treatment of
depression are still unknown. This study aimed to observe the effects of electroacupuncture …

Electroacupuncture Alleviates Depressive‐Like Symptoms and Modulates BDNF Signaling in 6‐Hydroxydopamine Rats

M Sun, K Wang, Y Yu, WT Su, XX Jiang… - Evidence‐Based …, 2016 - Wiley Online Library
Previous studies have identified the beneficial effects of electroacupuncture (EA) on motor
behaviors in Parkinson's disease (PD). However, the role and potential mechanisms of EA in …