Current state of theranostics in metastatic castrate‐resistant prostate cancer

U Nindra, P Lin, T Becker, TL Roberts… - Journal of Medical …, 2024 - Wiley Online Library
Prostate cancer remains one of the leading causes of cancer‐related death in the world.
There have been significant advances in chemotherapy, hormonal therapy and targeted …

The role of theranostics in prostate cancer

E O'Dwyer, L Bodei, MJ Morris - Seminars in radiation oncology, 2021 - Elsevier
Theranostics in men with metastatic castration-resistant prostate cancer (mCRPC) has been
developed to target bone and the tumor itself. Currently, bone-directed targeted alpha …

A treatment paradigm shift: targeted radionuclide therapies for metastatic castrate resistant prostate cancer

EE Parent, AM Kase - Cancers, 2022 - mdpi.com
Simple Summary Metastatic prostate cancer has traditionally been treated with a
combination of hormonal and chemotherapy regimens. With the recent FDA approval of …

The Outcome and Safety of Re-challenge Lutetium-177 PSMA (177Lu-PSMA) Therapy with Low-Dose Docetaxel as a Radiosensitizer—a Promising Combination in …

M Maharaj, L Heslop, T Govender, N Korowlay… - Nuclear Medicine and …, 2021 - Springer
Prostate-specific membrane antigen (PSMA)-directed radioligand therapy (PSMA-RLT) with
lutetium-177 (177 Lu-PSMA) has been used in metastatic castrate-resistant prostate cancer …

Evaluation of the tolerability and safety of [225Ac]Ac-PSMA-I&T in patients with metastatic prostate cancer: a phase I dose escalation study

S Ling, AAM van der Veldt, M Konijnenberg, M Segbers… - BMC cancer, 2024 - Springer
Background Life expectancy of patients with metastatic castration-resistant prostate cancer
(mCRPC) is still limited despite several systemic treatments. Within five years after diagnosis …

Third-line treatment and 177Lu-PSMA radioligand therapy of metastatic castration-resistant prostate cancer: a systematic review

FE von Eyben, G Roviello, T Kiljunen… - European journal of …, 2018 - Springer
Aims There is a controversy as to the relative efficacy of 177 Lu prostate specific membrane
antigen (PSMA) radioligand therapy (RLT) and third-line treatment for patients with …

Results of a 50 patient single-center phase II prospective trial of Lutetium-177 PSMA-617 theranostics in metastatic castrate-resistant prostate cancer.

M Hofman, JA Violet, RJ Hicks, J Ferdinandus… - 2019 - ascopubs.org
228 Background: Lutetium-177 (177Lu)-PSMA-617 (LuPSMA) is a radiolabelled small
molecule that binds with high affinity to prostate specific membrane antigen (PSMA) …

Advances in 177Lu-PSMA and 225Ac-PSMA Radionuclide Therapy for Metastatic Castration-Resistant Prostate Cancer

SW Ling, E de Blois, E Hooijman, A van der Veldt… - Pharmaceutics, 2022 - mdpi.com
For patients with metastatic castration-resistant prostate cancer (mCRPC), the survival
benefit of classic treatment options with chemotherapy and drugs targeting androgen …

Long-term follow-up and outcomes of retreatment in an expanded 50-patient single-center phase II prospective trial of 177Lu-PSMA-617 theranostics in metastatic …

J Violet, S Sandhu, A Iravani… - Journal of Nuclear …, 2020 - Soc Nuclear Med
177Lu-PSMA-617 is a radioligand with high affinity for prostate-specific membrane antigen
(PSMA), enabling targeted β-irradiation of prostate cancer. We have previously reported …

Lutetium-177 PSMA for the treatment of metastatic castrate resistant prostate cancer: a systematic review

K Patell, M Kurian, JA Garcia, P Mendiratta… - Expert Review of …, 2023 - Taylor & Francis
Introduction Metastatic castrate resistant prostate cancer (mCPRC) remains an aggressive
form of prostate cancer that no longer responds to traditional hormonal treatment alone …