A series of novel thieno [2, 3-d] pyrimidine analogs were designed and synthesized as
KRAS G12D inhibitors via combinatorial virtual screening approach. Most compounds …

Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …

In contrast to mitochondria in healthy cells, which utilize oxidative phosphorylation,
malignant cells undergo elevated glycolysis for energy production using glucose. The …

Abnormal activation of phosphoinositide 3-kinase (PI3K) signalling is very common in
cancer, leading to deregulation of several intracellular processes normally controlled by this …

An efficient synthesis of substituted pyrido [2, 3-d] pyrimidines was carried out and evaluated
for in vitro anticancer activity against five cancer cell lines, namely hepatic cancer (HepG-2) …

Molecular modeling was used to improve potency of the cyclohexylamine series. In addition,
a 3-D QSAR method was used to gain insight for reducing off-target DPP-8/9 activities …

CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a
selective manner. A new set of small molecules featuring the privileged pyrazolo [3, 4-d] …

Design and development of potential pyruvate dehydrogenase kinase 3 (PDK3) inhibitors
have gained attention because of their possible therapeutic uses in lung cancer therapy. In …

Cancer remains a lethal threat to global lives. Development of novel anticancer therapeutics
is still a challenge to scientists in the field of biomedicine. In cancer cells, the metabolic …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal
cancers in humans, due to late diagnosis and limited treatment possibilities. Improved …