Signal transduction of many growth factors and oncogenes is mediated by 3‐
phosphoinositide‐dependent protein kinase‐1 (PDK1), a master regulator of a number of …

Pyruvate dehydrogenase kinase 3 (PDK3) plays a central role in the cancer metabolic
switch through the reversible phosphorylation of pyruvate dehydrogenase complex thereby …

Pyruvate dehydrogenase kinases (PDKs) are key enzymes in glucose metabolism,
negatively regulating pyruvate dehyrogenase complex (PDC) activity through …

Analogues substituted with various amines at the 6-position of the pyrazine ring on (4-amino-
7-isopropyl-7H-pyrrolo [2, 3-d] pyrimidin-5-yl) pyrazin-2-ylmethanone were discovered as …

The phosphoinositide 3-kinase/AKT signaling pathway plays a key role in cancer cell
growth, survival, and angiogenesis. Phosphoinositide-dependent protein kinase-1 (PDK1) …

Hybridization of reported weakly active antiproliferative hit 5-amino-4-pyrimidinol derivative
with 2-anilino-4-phenoxypyrimidines suggests a series of 2, 5-diamino-4-pyrimidinol …

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase
kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells …

The mutation of cyclin dependent kinase inhibitor 2A (CDKN2A) is frequently found in
pancreatic ductal adenocarcinoma (PDAC). However, its prognostic and therapeutic roles in …

MAPK pathway sparkles with RTK activation, passes through subsequent downstream RAS-
RAF-MEK-ERK signaling cascades, with consequent direct and indirect CDK4/6 signaling …

Pancreatic cancer has a high mortality rate and its incidence has risen rapidly in recent
years. Meanwhile, the diagnosis and treatment of this cancer remain challenging. Pancreatic …