Shuttling of intermediary metabolites, such as pyruvate, contributes to the dynamic energy
and biosynthetic needs of tissues. Tracer kinetic studies offer a powerful tool to measure the …

The shuttling of intermediary metabolites such as lactate through the vasculature contributes
to the dynamic energy and biosynthetic needs of tissues. Tracer kinetic studies offer a …

The transport of pyruvate and lactate across cellular membranes is an essential process in
mammalian cells and is mediated by the H+/monocarboxylate transporters (MCTs). We have …

Because of the many energy-demanding functions they perform and their physical location
in the lung, alveolar epithelial type II (ATII) cells have a rapid cellular metabolism and the …

We describe the isotopic exchange of lactate and pyruvate after arm vein infusion of [3-13C]
lactate in men during rest and exercise. We tested the hypothesis that working muscle (limb …

The availability of genetically modified mice requires the development of methods to assess
heart function and metabolism in the intact beating organ. With the use of radioactive …

Although relatively metabolically inactive, the lung has an important role in maintaining
systemic glycolytic intermediate and cytosolic redox balance. Failure to perform this function …

Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a
branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial …

Pyruvate oxidation was studied in isolated guinea pig hearts perfused under various
conditions of work and stimulated by norepinephrine. Hearts metabolized pyruvate alone or …

The goal of this study was to measure flux through pyruvate carboxylation and
decarboxylation in the heart in vivo. These rates were measured in the anterior wall of …