Background: The large majority of depressed patients fail to remit on the first antidepressant
prescribed. These patients with residual symptoms have higher relapse rates and poorer …

Objective: Major depressive disorder (MDD) affects about 10–15% of the general population
in a lifetime. A considerable number of patients fail to achieve full symptom remission …

Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …

Previous comparative reviews of add-on therapies for patients with major depressive
disorder (MDD) with an inadequate response to antidepressants have not used meta …

Background Although antidepressants are often a first‐line treatment for adults with
moderate to severe depression, many people do not respond adequately to medication, and …

Background Antidepressants are a first‐line treatment for adults with moderate to severe
major depression. However, many people prescribed antidepressants for depression don't …

AIM: To review evidence supporting pharmacological treatments for treatment-resistant
depression (TRD) and to discuss them according to personal clinical experience …

Despite the large number of depressed patients who do not respond to first-line
antidepressants, the evidence base of alternate strategies is quite thin. In this article, a …

Objective: To examine the available scientific evidence for answers to clinically relevant
questions on the effectiveness and tolerability of antidepressant drugs (ADs) for the long …

A systematic review and random-effects model network meta-analysis were conducted to
compare the efficacy, acceptability, tolerability, and safety of antidepressants to treat adults …