Major depressive disorder (MDD) is associated with a significant burden and costs to the
society. As remission of depressive symptoms is achieved in only one-third of the MDD …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

BACKGROUND: Treatment-resistant depression (TRD) is relatively common and accounts
for a large proportion of the overall burden caused by depression. We conducted a …

Background It is commonly assumed that robust evidence exists for the lack of efficacy of
antidepressants at the milder end of the depression severity spectrum. In light of specific …

Background Varying conceptualizations of treatment‐resistant depression (TRD) have made
translating research findings or systematic reviews into clinical practice guidelines …

The objective of this research study was to assess pharmacological, somatic and/or
psychological treatments in adults with a diagnosis of major depressive disorder who have …

Background The efficacy, limitations, and methods of studying antidepressant treatment
continued beyond initial weeks of acute major depression remain incompletely resolved …

Introduction Pharmacotherapy plays an important role in the treatment of major depression.
At the initiation of antidepressant treatment, both improvement of symptoms in the short term …

Background Most adults with major depressive disorder (MDD) fail to achieve remission with
index pharmacological treatment. Moreover, at least half will not achieve and sustain …

Switching Antidepressant Class Does Not Improve Response or... : Journal of Clinical
Psychopharmacology Switching Antidepressant Class Does Not Improve Response or …