Objective Augmenting and switching antidepressant medications are the 2 most common
next-step strategies for depressed patients failing initial medication treatment. These …

Abstract Treatment-resistant depression (TRD) presents major challenges for both patients
and clinicians. There is no universally accepted definition of TRD, but results from the US …

Pharmacological treatment of major depressive disorder is often inefficient, and multiple
strategies are used for inadequate response to antidepressants. Second-generation …

Introduction: The authors describe the medications for treatment-resistant depression (TRD)
in phase II/III of clinical development in the EU and USA and provide an opinion on how …

Introduction Many antidepressants are indicated for the treatment of major depression. Two
network meta-analyses have provided the most comprehensive assessments to date …

Background We aimed to synthesize the available evidence on the relative efficacy and
acceptability of specific treatments for persistent depressive disorder. Methods We searched …

Objective: No universal definition for treatment-resistant depression (TRD) exists. This lack
of consensus reduces the generalizability of study findings and limits the ability to study …

Background: In patients who are not responding to antidepressant pharmacotherapy,
information regarding the future probability of response with the same treatment is scarce …

Objective: Up to 15% of depression patients eventually present with treatment-resistant or
refractory depression (TRD), a condition that causes significant social and economic …

The concept of full remission as the goal of treatment in major depressive disorder (MDD) is
becoming increasingly recognized. Investigators have increasingly begun to use remission …