An efficient synthesis of F18-FECNT, a PET tracer for dopamine transporter

D Murali, N Vandehey, B Christian, J Nickles, E Houser… - 2008 - Soc Nuclear Med
1229 Objectives: The aim of this work is to develop an efficient and cost effective method to
synthesize F18-FECNT, a PET tracer used for in vivo imaging of dopamine transporter …

A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent 18F-FECNT and its in vivo evaluations

S Liang, Z Chen, Y Ma, J Guo, H Wang - Journal of Radioanalytical and …, 2013 - Springer
Abstract 2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-[18 F] fluoroethyl) nortropane ([18 F]-
FECNT) is a potential dopamine transporter PET imaging agent. However, its current radio …

Synthesis and Biological Evaluation of [18F]FECNT-d4 as a Novel PET Agent for Dopamine Transporter Imaging

S Cao, J Tang, C Liu, Y Fang, L Ji, Y Xu… - Molecular Imaging and …, 2021 - Springer
Purpose The dopamine transporter (DAT) is a marker of the occurrence and development of
Parkinson's disease (PD) and other diseases with nigrostriatal degeneration. 2β …

Synthesis of a Dopamine Transporter Imaging Agent, N-(3-[]fluoropropyl)--carbomethoxy--(4-iodophenyl)nortropane

YS Choe, SJ Oh, DY Chi, SE Kim, Y Choi… - The Korean Journal …, 1999 - koreascience.kr
Purpose: N-(3-[$^{18} F $] Fluoropropyl)-$2 {\beta} $-carbomethoxy-$3 {\beta} $-(4-
iodophenyl) nortropane [$^{18} F $] FP-CIT) has been shown to be very useful for imaging …

One-step high-radiochemical-yield synthesis of [18F] FP-CIT using a protic solvent system

SJ Lee, SJ Oh, DY Chi, SH Kang, HS Kil, JS Kim… - Nuclear medicine and …, 2007 - Elsevier
Although [18F] fluoropropylcarbomethoxyiodophenylnortro… (FP-CIT) is a promising
radiopharmaceutical for dopamine transporter imaging, it has not been used for clinical …

PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements

SS Zoghbi, HU Shetty, M Ichise, M Fujita… - Journal of Nuclear …, 2006 - Soc Nuclear Med
18F-2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl) nortropane (18F-FECNT), a
PET radioligand for the dopamine transporter (DAT), generates a radiometabolite that enters …

[PDF][PDF] Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters

MM Goodman, R Keil, TM Shoup… - Journal of Nuclear …, 1997 - Soc Nuclear Med
Results: Tissue distributionstudies in rats with [18F] FPCTshowed high striatal uptake
(0.70% dose/g at 60 min; 0.38% dose/g at 120 min) and good striatal-to-cerebellum ratios …

A one-step automated high-radiochemical-yield synthesis of 18F-FECNT from mesylate precursor

ZP Chen, SP Wang, XM Li, CY Liu, J Tang… - Applied Radiation and …, 2008 - Elsevier
2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-[18F] fluoroethyl) nortropane (18F-FECNT) is a
potential dopamine transporter imaging agent. In this article, a new mesylate precursor was …

18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters

MM Goodman, CD Kilts, R Keil, B Shi… - Nuclear medicine and …, 2000 - Elsevier
Fluorine-18 labeled 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl) nortropane
(FECNT) was synthesized in the development of a dopamine transporter (DAT) imaging …

Synthesis of novel halo and tosyloxy nortropane derivatives as efficient precursors for the one‐step synthesis of the dopamine transporter PET ligand [18F]FECNT

J Pijarowska‐Kruszyna, AW Jaron… - Journal of Labelled …, 2014 - Wiley Online Library
The fluorine‐18 labeled nortropane derivative 2β‐carbomethoxy‐3β‐(4‐chlorophenyl)‐8‐(2‐
fluoroethyl)‐nortropane (FECNT) is a dopamine transporter (DAT) ligand. Currently, it is …