DAMPs from cell death to new life

E Vénéreau, C Ceriotti, ME Bianchi - Frontiers in immunology, 2015 - frontiersin.org
Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

DAMPs activating innate immune responses in sepsis

JW Kang, SJ Kim, HI Cho, SM Lee - Ageing research reviews, 2015 - Elsevier
Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the
host to microbial infection and is the leading cause of death in intensive care units. The …

DAMPs and DAMP-sensing receptors in inflammation and diseases

M Ma, W Jiang, R Zhou - Immunity, 2024 - cell.com
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

T Gong, L Liu, W Jiang, R Zhou - Nature Reviews Immunology, 2020 - nature.com
The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Complexity of danger: the diverse nature of damage-associated molecular patterns

L Schaefer - Journal of Biological Chemistry, 2014 - ASBMB
In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular …

Damage-associated molecular patterns and the systemic immune consequences of severe thermal injury

PB Comish, D Carlson, R Kang… - The journal of immunology, 2020 - journals.aai.org
Thermal injury is often associated with a proinflammatory state resulting in serious
complications. After a burn, the innate immune system is activated with subsequent immune …

Release mechanisms of major DAMPs

A Murao, M Aziz, H Wang, M Brenner, P Wang - Apoptosis, 2021 - Springer
Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment
inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically …

Damage-associated molecular patterns in cancer: a double-edged sword

C Hernandez, P Huebener, RF Schwabe - Oncogene, 2016 - nature.com
Damage-associated molecular patterns (DAMPs) are released in response to cell death and
stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs …

Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

A Rubartelli, MT Lotze - Trends in immunology, 2007 - cell.com
Immune responses are initiated and perpetuated by molecules derived from microorganisms
pathogen-associated molecular-pattern molecules or from the damage or death of host cells …

Key role of DAMP in inflammation, cancer, and tissue repair

F Pandolfi, S Altamura, S Frosali, P Conti - Clinical therapeutics, 2016 - Elsevier
Purpose This review aimed to take stock of the current status of research on damage-
associated molecular pattern (DAMP) protein. We discuss the Janus-faced role of DAMP …