Fibrosis in response to tissue damage or persistent inflammation is a pathological hallmark
of many chronic degenerative diseases. By using a model of acute peritoneal inflammation …

Fibrosis is a detrimental outcome of most chronic inflammatory disorders and is defined by
the buildup of excess extracellular matrix (ECM) components, which eventually leads to …

Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the
skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue …

Interleukin-6 is a classic pro-inflammatory cytokine needed to mount an effective immune
response. It is secreted by a wide array of cell types, however, its target cells are more …

Interleukin 6 (IL-6) is a 184-amino acid protein cytokine that is produced by many types of
cells and is expressed during states of cellular stress, such as inflammation, infection …

Dysregulated wound healing leads to fibrosis, whereby fibroblasts synthesize excess
extracellular matrix and scarring impairs proper organ function. Although fibrotic diseases …

Importance of chronic fibroproliferative diseases (FDs) including pulmonary fibrosis, chronic
kidney diseases, inflammatory bowel disease, and cardiovascular or liver fibrosis is rapidly …

Damage-induced fibrotic scarring limits tissue regeneration in mammals and is a leading
cause of morbidity. In contrast, species like zebrafish can regenerate damaged tissues …

The timely resolution of wound healing is critical for restoring the skin as a protective barrier.
The switch from a proinflammatory to a reparative microenvironment must be tightly …

Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as
systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease …