Understanding multifactorial architecture of Parkinson's disease: pathophysiology to management

R Kaur, S Mehan, S Singh - Neurological Sciences, 2019 - Springer
Parkinson's disease (PD) is the second most common multifactorial neurodegenerative
disorder affecting 3% of population during elder age. The loss of substantia nigra, pars …

[HTML][HTML] The overcrowded crossroads: mitochondria, alpha-synuclein, and the endo-lysosomal system interaction in Parkinson's disease

KJ Lin, KL Lin, SD Chen, CW Liou, YC Chuang… - International journal of …, 2019 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder
worldwide, mainly affecting the elderly. The disease progresses gradually, with core motor …

[HTML][HTML] The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease

SYY Pang, PWL Ho, HF Liu, CT Leung, L Li… - Translational …, 2019 - Springer
Background Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the
substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During …

Common mechanisms underlying α-synuclein-induced mitochondrial dysfunction in Parkinson's disease

T Sohrabi, B Mirzaei-Behbahani, R Zadali… - Journal of Molecular …, 2023 - Elsevier
Parkinson's disease (PD) is the most common neurological movement disorder
characterized by the selective and irreversible loss of dopaminergic neurons in substantia …

[HTML][HTML] Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease

S Gallegos, C Pacheco, C Peters, CM Opazo… - Frontiers in …, 2015 - frontiersin.org
Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system,
and it is the main component of Lewy bodies, one of the histopathological features of …

Alpha-synuclein toxicity on protein quality control, mitochondria and endoplasmic reticulum

TQ Melo, SJ Copray, MFR Ferrari - Neurochemical research, 2018 - Springer
Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters
containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and …

[HTML][HTML] Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective

S Yi, L Wang, H Wang, MS Ho, S Zhang - International Journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …

[HTML][HTML] Pathological and therapeutic advances in Parkinson's disease: mitochondria in the interplay

P Naren, A Cholkar, S Kamble, SS Khan… - Journal of …, 2023 - content.iospress.com
Parkinson's disease (PD) is the second most common neurodegenerative illness majorly
affecting the population between the ages of 55 to 65 years. Progressive dopaminergic …

[HTML][HTML] Alpha-synuclein aggregation in Parkinson's disease

E Srinivasan, G Chandrasekhar… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …

[HTML][HTML] Mitochondrial dysfunction, protein misfolding and neuroinflammation in Parkinson's disease: roads to biomarker discovery

A Picca, F Guerra, R Calvani, R Romano… - Biomolecules, 2021 - mdpi.com
Parkinson's Disease (PD) is a highly prevalent neurodegenerative disease among older
adults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons …