Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density

MJ Wilhelm, HH Ong, SL Wehrli, C Li… - Proceedings of the …, 2012 - National Acad Sciences
Magnetic resonance imaging has previously demonstrated its potential for indirectly
mapping myelin density, either by relaxometric detection of myelin water or magnetization …

Towards quantification of myelin by solid-state MRI of the lipid matrix protons

AC Seifert, C Li, MJ Wilhelm, SL Wehrli, FW Wehrli - NeuroImage, 2017 - Elsevier
Purpose Direct assessment of myelin has the potential to reveal central nervous system
abnormalities and serve as a means to follow patients with demyelinating disorders during …

In vivo visualization of myelin water in brain by magnetic resonance

A Mackay, K Whittall, J Adler, D Li… - Magnetic resonance …, 1994 - Wiley Online Library
We exploit the intrinsic difference in magnetic resonance spin‐spin relaxation time, T2,
between water associated with myelin sheaths and water in other central nervous system …

[HTML][HTML] Magnetic resonance of myelin water: an in vivo marker for myelin

AL MacKay, C Laule - Brain plasticity, 2016 - content.iospress.com
Myelin is critical for healthy brain function. An accurate in vivo measure of myelin content
has important implications for understanding brain plasticity and neurodegenerative …

Probing myelin content of the human brain with MRI: A review

GF Piredda, T Hilbert, JP Thiran… - Magnetic resonance in …, 2021 - Wiley Online Library
Rapid and efficient transmission of electric signals among neurons of vertebrates is ensured
by myelin‐insulating sheaths surrounding axons. Human cognition, sensation, and motor …

[HTML][HTML] Magnetic resonance imaging of myelin

C Laule, IM Vavasour, SH Kolind, DKB Li… - …, 2007 - Elsevier
The ability to measure myelin in vivo has great consequences for furthering our knowledge
of normal development, as well as for understanding a wide range of neurological disorders …

Myelin water measurement in the spinal cord

EP Minty, TA Bjarnason, C Laule… - Magnetic Resonance in …, 2009 - Wiley Online Library
The desire to monitor the spatial–temporal characteristics of myelination in the spinal cord
(SC), in the context of pathological change in demyelinating diseases or proposed …

High‐resolution myelin water measurements in rat spinal cord

P Kozlowski, J Liu, AC Yung… - Magnetic Resonance in …, 2008 - Wiley Online Library
Multiecho imaging data were acquired at 7T from control and injured (dorsal column
transection) rat spinal cords ex vivo with in‐plane resolution of 61, 78, and 100 μm, and from …

Myelin water imaging to detect demyelination and remyelination and its validation in pathology

C Laule, GRW Moore - Brain Pathology, 2018 - Wiley Online Library
Damage to myelin is a key feature of multiple sclerosis (MS) pathology. Magnetic resonance
imaging (MRI) has revolutionized our ability to detect and monitor MS pathology in vivo …

Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields

C Labadie, JH Lee, WD Rooney… - Magnetic resonance …, 2014 - Wiley Online Library
Purpose Magnetic resonance T1‐weighted images are routinely used for human brain
segmentation, brain parcellation, and clinical diagnosis of demyelinating diseases. Myelin is …