The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence
Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …
Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine
C Flores, C Manitt, D Rodaros, KM Thompson… - Molecular …, 2005 - nature.com
Netrins are guidance cues that play a fundamental role in organizing the developing brain.
The netrin receptor, DCC (deleted in colorectal cancer), is highly expressed by …
The netrin receptor, DCC (deleted in colorectal cancer), is highly expressed by …
The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry
C Manitt, A Mimee, C Eng, M Pokinko… - Journal of …, 2011 - Soc Neuroscience
Netrins are guidance cues involved in neural connectivity. We have shown that the netrin-1
receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the …
receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the …
Netrin‐1 receptor‐deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine
A Grant, D Hoops, C Labelle‐Dumais… - European Journal of …, 2007 - Wiley Online Library
The mesocorticolimbic dopamine (DA) system is implicated in neurodevelopmental
psychiatric disorders including schizophrenia but it is unknown how disruptions in brain …
psychiatric disorders including schizophrenia but it is unknown how disruptions in brain …
Making dopamine connections in adolescence
A dramatic maturational process ongoing in adolescence is prefrontal cortex development,
including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal …
including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal …
Regulation of netrin-1 receptors by amphetamine in the adult brain
L Yetnikoff, C Labelle-Dumais, C Flores - Neuroscience, 2007 - Elsevier
Netrin-1 is a guidance cue molecule fundamental to the organization of neuronal
connectivity during development. Netrin-1 and its receptors, deleted in colorectal cancer …
connectivity during development. Netrin-1 and its receptors, deleted in colorectal cancer …
Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system
C Flores - Journal of Psychiatry and Neuroscience, 2011 - jpn.ca
Changes in mesocorticolimbic dopamine (DA) neurons and their target cells can be induced
throughout life and are important determinants of individual differences in susceptibility to …
throughout life and are important determinants of individual differences in susceptibility to …
Netrin‐1 receptor in the ventral tegmental area is required for sensitization to amphetamine
L Yetnikoff, C Eng, S Benning… - European Journal of …, 2010 - Wiley Online Library
Fundamental to neural organization during development, the netrin‐1 guidance cue and its
receptor, deleted in colorectal cancer (DCC), continue to be expressed in the adult brain. We …
receptor, deleted in colorectal cancer (DCC), continue to be expressed in the adult brain. We …
Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents
C Manitt, C Labelle-Dumais, C Eng, A Grant, A Mimee… - PloS one, 2010 - journals.plos.org
Puberty is a critical period in mesocorticolimbic dopamine (DA) system development,
particularly for the medial prefrontal cortex (mPFC) projection which achieves maturity in …
particularly for the medial prefrontal cortex (mPFC) projection which achieves maturity in …
Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization
B Xu, JS Goldman, VV Rymar, C Forget, PS Lo, SJ Bull… - Neuroscience, 2010 - Elsevier
DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is highly
expressed by mesencephalic dopaminergic (DA) neurons during development; however …
expressed by mesencephalic dopaminergic (DA) neurons during development; however …