The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence

DE Vosberg, M Leyton, C Flores - Molecular psychiatry, 2020 - nature.com
Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine

C Flores, C Manitt, D Rodaros, KM Thompson… - Molecular …, 2005 - nature.com
Netrins are guidance cues that play a fundamental role in organizing the developing brain.
The netrin receptor, DCC (deleted in colorectal cancer), is highly expressed by …

The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry

C Manitt, A Mimee, C Eng, M Pokinko… - Journal of …, 2011 - Soc Neuroscience
Netrins are guidance cues involved in neural connectivity. We have shown that the netrin-1
receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the …

Netrin‐1 receptor‐deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine

A Grant, D Hoops, C Labelle‐Dumais… - European Journal of …, 2007 - Wiley Online Library
The mesocorticolimbic dopamine (DA) system is implicated in neurodevelopmental
psychiatric disorders including schizophrenia but it is unknown how disruptions in brain …

Making dopamine connections in adolescence

D Hoops, C Flores - Trends in neurosciences, 2017 - cell.com
A dramatic maturational process ongoing in adolescence is prefrontal cortex development,
including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal …

Regulation of netrin-1 receptors by amphetamine in the adult brain

L Yetnikoff, C Labelle-Dumais, C Flores - Neuroscience, 2007 - Elsevier
Netrin-1 is a guidance cue molecule fundamental to the organization of neuronal
connectivity during development. Netrin-1 and its receptors, deleted in colorectal cancer …

Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system

C Flores - Journal of Psychiatry and Neuroscience, 2011 - jpn.ca
Changes in mesocorticolimbic dopamine (DA) neurons and their target cells can be induced
throughout life and are important determinants of individual differences in susceptibility to …

Netrin‐1 receptor in the ventral tegmental area is required for sensitization to amphetamine

L Yetnikoff, C Eng, S Benning… - European Journal of …, 2010 - Wiley Online Library
Fundamental to neural organization during development, the netrin‐1 guidance cue and its
receptor, deleted in colorectal cancer (DCC), continue to be expressed in the adult brain. We …

Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents

C Manitt, C Labelle-Dumais, C Eng, A Grant, A Mimee… - PloS one, 2010 - journals.plos.org
Puberty is a critical period in mesocorticolimbic dopamine (DA) system development,
particularly for the medial prefrontal cortex (mPFC) projection which achieves maturity in …

Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization

B Xu, JS Goldman, VV Rymar, C Forget, PS Lo, SJ Bull… - Neuroscience, 2010 - Elsevier
DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is highly
expressed by mesencephalic dopaminergic (DA) neurons during development; however …