Intranasal immunization induces long-term protection in mice against a Chlamydia trachomatis genital challenge

S Pal, EM Peterson, LM De La Maza - Infection and immunity, 1996 - Am Soc Microbiol
In an attempt to confer long-term protective immunity, BALB/c female mice were immunized
intranasally with 10 (4) inclusion-forming units (IFU) of the Chlamydia trachomatis mouse …

Protection against infertility in a BALB/c mouse salpingitis model by intranasal immunization with the mouse pneumonitis biovar of Chlamydia trachomatis

S Pal, TJ Fielder, EM Peterson… - Infection and …, 1994 - Am Soc Microbiol
Female BALB/c mice were immunized intranasally with the mouse pneumonitis biovar of
Chlamydia trachomatis and subsequently challenged in the ovarian bursa (C. trachomatis …

Intranasal immunization with Chlamydia trachomatis, serovar E, protects from a subsequent vaginal challenge with the homologous serovar

EM Peterson, JZ You, V Motin, LM de la Maza - Vaccine, 1999 - Elsevier
To vaccinate against a vaginal challenge with Chlamydia trachomatis, C3H/HeJ (H-2k) mice
were immunized intranasally (in) or intraperitoneally (ip) with 1× 106 inclusion forming units …

Induction of protective immunity against a Chlamydia trachomatis genital infection in three genetically distinct strains of mice

S Pal, EM Peterson, LM De La Maza - Immunology, 2003 - Wiley Online Library
To establish the feasibility of inducing a protective immune response against a chlamydial
genital infection in animals with different genetic backgrounds, groups of C3H/HeN (H‐2k) …

Vaccination with the Chlamydia trachomatis Major Outer Membrane Protein Can Elicit an Immune Response as Protective as That Resulting from Inoculation with …

S Pal, EM Peterson, LM de la Maza - Infection and immunity, 2005 - Am Soc Microbiol
ABSTRACT BALB/c mice were vaccinated by the intramuscular (im) and subcutaneous (sc)
routes with a native preparation of the Chlamydia trachomatis mouse pneumonitis (MoPn) …

Induction of antibody response to Chlamydia trachomatis in the genital tract by oral immunization

ZD Cui, D Tristram, LJ LaScolea… - Infection and …, 1991 - Am Soc Microbiol
Groups of BALB/c mice were orally immunized with Chlamydia trachomatis serovar
L2/434/Bu in order to characterize the nature and kinetics of the chlamydial antibody …

Immunization with an acellular vaccine consisting of the outer membrane complex of Chlamydia trachomatis induces protection against a genital challenge

S Pal, I Theodor, EM Peterson… - Infection and …, 1997 - Am Soc Microbiol
The ability to induce protection against a genital challenge was studied in BALB/c female
mice with three Chlamydia trachomatis mouse pneumonitis (MoPn) major outer membrane …

Transcervical inoculation with Chlamydia trachomatis induces infertility in HLA-DR4 transgenic and wild-type mice

S Pal, DF Tifrea, G Zhong, LM de la Maza - Infection and immunity, 2018 - Am Soc Microbiol
Chlamydia trachomatis is the leading cause of infection-induced infertility in women.
Attempts to control this epidemic with screening programs and antibiotic therapy have failed …

Protective immunity to chlamydial genital infection: evidence from animal studies

RG Rank, JA Whittum-Hudson - The Journal of infectious …, 2010 - academic.oup.com
In all animal models for chlamydial infection, there is strong evidence for immunity to
reinfection; however, immunity is only complete (ie, preventing infection) in the short term. In …

Intranasal Vaccination with a Secreted Chlamydial Protein Enhances Resolution of Genital Chlamydia muridarum Infection, Protects against Oviduct Pathology, and …

AK Murthy, JP Chambers, PA Meier, G Zhong… - Infection and …, 2007 - Am Soc Microbiol
There is currently no licensed vaccine against Chlamydia trachomatis, the leading cause of
sexually transmitted bacterial disease worldwide. Conventional vaccination attempts using …