T cells are known to migrate to B‐cell‐enriched follicles and germinal centers within
secondary lymphoid organs to provide help to B cells. Cognate T: B interactions that take …

T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in
germinal centers (GCs), specialized secondary lymphoid organ structures dedicated to …

The discovery that Bcl-6 was the transcriptional regulator of follicular helper T (Tfh) cells
completed the recognition of this population as an effector subset specialized in the …

T follicular helper cells (Tfh cells) localize to follicles where they provide growth and
selection signals to mutated germinal center (GC) B cells, thus promoting their differentiation …

Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

Follicular T‐helper (TFH) cells play a crucial role in three aspects of the germinal center
(GC) response. They promote GC formation, arbitrate competition among GC B cells to …

Germinal center (GC) B cells undergo affinity selection, which depends on interactions with
CD4+ follicular helper T cells (TFH cells). We found that TFH cells progressed through …

T-follicular helper (Tfh) cells differentiate through a multistep process, culminating in
germinal center (GC) localized GC-Tfh cells that provide support to GC-B cells. T-follicular …

Highlights•Tfh and GC response is hyperactivated in human autoimmune
diseases.•Aberrant Tfh response can be monitored by the analysis of cTfh cells.•Inflamed …

Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that
induce the differentiation of B cells into plasma cells and memory cells. They are found …