Identification of atrial fibrillation associated genes and functional non-coding variants

AF van Ouwerkerk, FM Bosada… - Nature …, 2019 - nature.com
Disease-associated genetic variants that lie in non-coding regions found by genome-wide
association studies are thought to alter the functionality of transcription regulatory elements …

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

JB Nielsen, RB Thorolfsdottir, LG Fritsche, W Zhou… - Nature …, 2018 - nature.com
To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …

Multi-ethnic genome-wide association study for atrial fibrillation

C Roselli, MD Chaffin, LC Weng, S Aeschbacher… - Nature …, 2018 - nature.com
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

IE Christophersen, M Rienstra, C Roselli, X Yin… - Nature …, 2017 - nature.com
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …

Epigenetic and transcriptional networks underlying atrial fibrillation

AF van Ouwerkerk, AW Hall, ZA Kadow… - Circulation …, 2020 - Am Heart Assoc
Genome-wide association studies have uncovered over a 100 genetic loci associated with
atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci …

Genetic control of left atrial gene expression yields insights into the genetic susceptibility for atrial fibrillation

J Hsu, S Gore-Panter, G Tchou, L Castel… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: Genome-wide association studies have identified 23 loci for atrial fibrillation
(AF), but the mechanisms responsible for these associations, as well as the causal genes …

Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility

KK Patel, C Venkatesan, H Abdelhalim, S Zeeshan… - Human genomics, 2023 - Springer
Atrial fibrillation (AF) and heart failure (HF) contribute to about 45% of all cardiovascular
disease (CVD) deaths in the USA and around the globe. Due to the complex nature …

Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development

JB Nielsen, LG Fritsche, W Zhou, TM Teslovich… - The American Journal of …, 2018 - cell.com
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart
failure, and premature death. The pathogenesis of AF remains poorly understood, which …

Identification of functional variant enhancers associated with atrial fibrillation

AF van Ouwerkerk, FM Bosada, J Liu, J Zhang… - Circulation …, 2020 - Am Heart Assoc
Rationale: Genome-wide association studies have identified a large number of common
variants (single-nucleotide polymorphisms) associated with atrial fibrillation (AF). These …

Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation

MF Sinner, NR Tucker, KL Lunetta, K Ozaki, JG Smith… - Circulation, 2014 - Am Heart Assoc
Background—Atrial fibrillation (AF) affects> 30 million individuals worldwide and is
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable …