Identification of atrial fibrillation associated genes and functional non-coding variants
AF van Ouwerkerk, FM Bosada… - Nature …, 2019 - nature.com
Disease-associated genetic variants that lie in non-coding regions found by genome-wide
association studies are thought to alter the functionality of transcription regulatory elements …
association studies are thought to alter the functionality of transcription regulatory elements …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
Multi-ethnic genome-wide association study for atrial fibrillation
C Roselli, MD Chaffin, LC Weng, S Aeschbacher… - Nature …, 2018 - nature.com
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …
heritability. We conducted the largest meta-analysis of genome-wide association studies …
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
IE Christophersen, M Rienstra, C Roselli, X Yin… - Nature …, 2017 - nature.com
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …
Epigenetic and transcriptional networks underlying atrial fibrillation
AF van Ouwerkerk, AW Hall, ZA Kadow… - Circulation …, 2020 - Am Heart Assoc
Genome-wide association studies have uncovered over a 100 genetic loci associated with
atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci …
atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci …
Genetic control of left atrial gene expression yields insights into the genetic susceptibility for atrial fibrillation
J Hsu, S Gore-Panter, G Tchou, L Castel… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: Genome-wide association studies have identified 23 loci for atrial fibrillation
(AF), but the mechanisms responsible for these associations, as well as the causal genes …
(AF), but the mechanisms responsible for these associations, as well as the causal genes …
Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility
KK Patel, C Venkatesan, H Abdelhalim, S Zeeshan… - Human genomics, 2023 - Springer
Atrial fibrillation (AF) and heart failure (HF) contribute to about 45% of all cardiovascular
disease (CVD) deaths in the USA and around the globe. Due to the complex nature …
disease (CVD) deaths in the USA and around the globe. Due to the complex nature …
Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart
failure, and premature death. The pathogenesis of AF remains poorly understood, which …
failure, and premature death. The pathogenesis of AF remains poorly understood, which …
Identification of functional variant enhancers associated with atrial fibrillation
AF van Ouwerkerk, FM Bosada, J Liu, J Zhang… - Circulation …, 2020 - Am Heart Assoc
Rationale: Genome-wide association studies have identified a large number of common
variants (single-nucleotide polymorphisms) associated with atrial fibrillation (AF). These …
variants (single-nucleotide polymorphisms) associated with atrial fibrillation (AF). These …
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation
Background—Atrial fibrillation (AF) affects> 30 million individuals worldwide and is
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable …
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable …
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