Short double-stranded RNAs, known as short interfering RNA (siRNA), can be used to
specifically down-regulate the expression of targeted genes in a process known as RNA …

Nucleic acid therapy is an emerging field of modern medicine. Therapeutic nucleic acids, in
particular, siRNA, are widely studied as prospective drugs for targeted modulation of gene …

Gene delivery is an inclusive step of gene therapy. Gene therapy can be defined as the
technique for treating the genetic disorders by the transmitting the genetic material into the …

Small interfering RNAs (siRNA) are emerging as novel therapeutic agents, providing
competent delivery systems that are available. Dendrimers, a special family of synthetic …

The potent ability of small interfering RNA (siRNA) to specifically and efficiently inhibit the
expression of complementary RNA transcripts offers a promising alternative therapeutic …

This paper examines a perspective on the use of newly engineered nanomaterials as
effective and safe carriers of genes for the therapy of cancer. Three different groups of …

Although siRNA techniques have been broadly applied as a tool for gene knockdown,
substantial challenges remain in achieving efficient delivery and in vivo efficacy. In …

Polyamidoamine dendrimers (PAMAM) form positively charged nanoparticles that function
as nonviral delivery vectors for gene therapy. They protect nucleic acids from enzymatic …

The application of siRNA in gene therapy is mainly limited because of the problems with its
transport into cells. Utilization of cationic dendrimers as siRNA carriers seems to be a …

PAMAM dendrimers for efficient siRNA delivery and potent gene silencing - Chemical
Communications (RSC Publishing) DOI:10.1039/B601381C Royal Society of Chemistry View …