Vertebrate neural tube formation involves two distinct morphogenetic events—convergent
extension (CE) driven by mediolateral cell intercalation, and bending of the neural plate …

Background Shaping of the neural tube, the precursor of the brain and spinal cord, involves
narrowing and elongation of the neural tissue, concomitantly with other morphogenetic …

The vertebrate nervous system arises through a series of inductive interactions, beginning
with the induction of the neural plate and the rostrocaudal patterning of the neural tube. The …

During development, a flat neural plate rolls up and closes to form a neural tube. This
process, called neural tube closure, is complex and requires morphogenetic events to occur …

The development of the embryonic brain critically depends on successfully completing
cranial neural tube closure (NTC). Failure to properly close the neural tube results in …

How control of subcellular events in single cells determines morphogenesis on the scale of
the tissue is largely unresolved. The stereotyped cross-midline mitoses of progenitors in the …

During neural tube formation, neural plate cells migrate from the lateral aspects of the dorsal
surface towards the midline. Elevation of the lateral regions of the neural plate produces the …

The initiation of nascent projections, or neurites, from the neuronal cell body is the first stage
in the formation of axons and dendrites, and thus a critical step in the establishment of …

The central nervous system of vertebrate embryos originates from the neural tube (NT), a
simple epithelium surrounding a central lumen. The mechanisms underlying the shaping of …