Current status and future challenges in extraction, purification and identification of Cepharanthine (a potential drug against COVID-19)

Y Wang, X Zhou, S Wei, G Wang, J Xi - Separation and Purification …, 2023 - Elsevier
With the outbreak of the new coronavirus disease 2019 (COVID-19), the rapid spread of the
virus has brought huge economic losses and life threats to the world. So far, we have …

[HTML][HTML] Pharmacological effects and clinical prospects of cepharanthine

D Liang, Q Li, L Du, G Dou - Molecules, 2022 - mdpi.com
Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha
Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has …

[HTML][HTML] The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug …

B Xia, L Zheng, Y Li, W Sun, Y Liu, L Li… - Frontiers in …, 2023 - frontiersin.org
To effectively respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
an increasing number of researchers are focusing on the antiviral activity of cepharanthine …

[HTML][HTML] Unraveling the mechanism of action of cepharanthine for the treatment of novel coronavirus pneumonia (COVID-19) from the perspectives of systematic …

F Sun, J Liu, A Tariq, Z Wang, Y Wu, L Li - Arabian Journal of Chemistry, 2023 - Elsevier
Natural products play an irreplaceable role in the treatment of SARS-CoV-2 infection.
Nevertheless, the underlying molecular mechanisms involved remain elusive. To better …

[HTML][HTML] Pharmacological activity of cepharanthine

K Liu, B Hong, S Wang, F Lou, Y You, R Hu, A Shafqat… - Molecules, 2023 - mdpi.com
Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant
Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for …

[HTML][HTML] Cepharanthine: A review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19

M Rogosnitzky, P Okediji, I Koman - Pharmacological Reports, 2020 - Springer
Cepharanthine (CEP) is a naturally occurring alkaloid derived from Stephania cepharantha
Hayata and demonstrated to have unique anti-inflammatory, antioxidative …

[HTML][HTML] Bioavailability enhancement of cepharanthine via pulmonary administration in rats and its therapeutic potential for pulmonary fibrosis associated with COVID …

J Li, G Chen, Z Meng, Z Wu, H Gan, X Zhu, P Han, T Liu… - Molecules, 2022 - mdpi.com
Cepharanthine (CEP) has excellent anti-SARS-CoV-2 properties, indicating its favorable
potential for COVID-19 treatment. However, its application is challenged by its poor …

Natural products homoharringtonine and emetine alkaloids as sars-Cov-2 treatment options

SS Sohrab, M Suhail, MA Kamal… - Current Pharmaceutical …, 2021 - ingentaconnect.com
Background: Viruses are known as the major causative agents for infectious diseases
globally. The coronaviruses are one of the serious pathogens to cause serious diseases in …

[HTML][HTML] Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery

L Leng, Z Xu, B Hong, B Zhao, Y Tian, C Wang… - Nature …, 2024 - nature.com
Cepharanthine is a secondary metabolite isolated from Stephania. It has been reported that
it has anti-conronaviruses activities including severe acute respiratory syndrome …

Unveiling the potential of Cepharanthine from plant to patient-A comprehensive review of phytochemistry, pharmacology and clinical investigations

S Dobhal, M Nandave, V Tiwari… - Journal of Biologically …, 2024 - Taylor & Francis
Cepharanthine (CEP), a cyclic alkaloid derived from several Stephania genus species, has
been widely utilized in Japan since the 1950s to address a range of ailments. CEP is an …