The single C. elegans member of the retinoblastoma gene family, lin-35 Rb, was originally
identified as a synthetic Multivulva (synMuv) gene [1]. These genes form two redundant …

Background Biological timing mechanisms that integrate cyclical and successive processes
are not well understood. C. elegans molting cycles involve rhythmic cellular and animal …

In Caenorhabditis elegans, the heterochronic pathway controls the timing of developmental
events during the larval stages. A component of this pathway, the let-7 small regulatory RNA …

The Caenorhabditis elegans maternal-effect clk genes are involved in the temporal control
of development and behavior. We report the genetic and molecular characterization of clk-2 …

LIN-12 and GLP-1 are members of the LIN-12/Notch family of receptors that mediate cell–
cell interactions during development. The sel-8 gene had been identified previously in a …

Molecular mechanisms control the timing, sequence, and synchrony of developmental
events in multicellular organisms. In Caenorhabditis elegans, these mechanisms are …

Development is typically studied as a continuous process under laboratory conditions, but
wild animals often develop in variable and stressful environments. C. elegans larvae hatch …

Horvitz lab (Ruvkun et al., 1989), and Gary went on to mid 1970s through the isolation of a
mutation (e912). sequence the lin-14 (a novel nuclear protein) gene in his The remarkable …

LIN28 is an RNA-binding protein that is expressed in many developing tissues. It can block
let-7 (Mirlet7) microRNA processing and help promote pluripotency. We have observed …

Under conditions unfavorable to growth, the nematode Caenorhabditis elegans enters a
developmentally arrested stage, the dauer larva. We have examined gene expression in the …