Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine

S Ylä-Herttuala, TT Rissanen, I Vajanto… - Journal of the american …, 2007 - jacc.org
Members of the vascular endothelial growth factor (VEGF) family are among the most
powerful modulators of vascular biology. They regulate vasculogenesis, angiogenesis, and …

Vascular endothelial growth factors in cardiovascular medicine

U Testa, G Pannitteri, GL Condorelli - Journal of Cardiovascular …, 2008 - journals.lww.com
The discovery of vascular endothelial growth factors (VEGFs) and their receptors has
considerably improved the understanding of the development and function of endothelial …

Vascular protection: a novel nonangiogenic cardiovascular role for vascular endothelial growth factor

I Zachary, A Mathur, S Yla-Herttuala… - … , and vascular biology, 2000 - Am Heart Assoc
There is widespread interest in the use of the angiogenic cytokine, vascular endothelial
growth factor (VEGF), for the treatment of cardiovascular disease. The main paradigm for …

Review of preclinical and clinical results with vascular endothelial growth factors for therapeutic angiogenesis.

TD Henry, JA Abraham - Current interventional cardiology reports, 2000 - europepmc.org
Therapeutic angiogenesis is a novel approach to the treatment of coronary and peripheral
vascular disease not amenable to standard revascularization techniques. Vascular …

Vascular endothelial growth factor: much more than an angiogenesis factor

DR Senger - Molecular biology of the cell, 2010 - Am Soc Cell Biol
Vascular endothelial growth factor (VEGF) is best known as a cytokine essential for
embryonic vasculogenesis and for the angiogenesis associated with various pathologies …

Vascular endothelial growth factor and angiogenesis

ANN Hoeben, B Landuyt, MS Highley, H Wildiers… - Pharmacological …, 2004 - ASPET
Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …

Vascular endothelial growth factor molecular and biological aspects

N Ferrara, HP Gerber - Advances in organ biology, 1999 - Elsevier
Vascular Endothelial Growth Factor (VEGF) is an endothelial cell-specific mitogen in vitro
and an angiogenic inducer in a variety of in vivo models. The tyrosine kinases Flt-1 and KDR …

Vascular endothelial growth factor

N Ferrara - Arteriosclerosis, thrombosis, and vascular biology, 2009 - Am Heart Assoc
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and
pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the …

Molecular and biological properties of vascular endothelial growth factor

N Ferrara - Journal of molecular medicine, 1999 - Springer
Vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and
abnormal angiogenesis. Recent evidence indicates that VEGF is essential for embryonic …

Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects

I Zachary, RD Morgan - Heart, 2011 - heart.bmj.com
Since the discovery of vascular endothelial growth factor (VEGF), therapeutic angiogenesis
has attracted interest as an alternative treatment for ischaemic heart and peripheral disease …