Regulation of ZEB1 function and molecular associations in tumor progression and metastasis

M Perez-Oquendo, DL Gibbons - Cancers, 2022 - mdpi.com
Simple Summary Given the importance of the epithelial-to-mesenchymal transition in tumor
progression and the pivotal role of ZEB1 as a transcriptional repressor during this process …

Post-translational modification of ZEB family members in cancer progression

MK Park, H Lee, CH Lee - International Journal of Molecular Sciences, 2022 - mdpi.com
Post-translational modification (PTM), the essential regulatory mechanisms of proteins, play
essential roles in physiological and pathological processes. In addition, PTM functions in …

The crucial role of ZEB2: from development to epithelial‐to‐mesenchymal transition and cancer complexity

M Fardi, M Alivand, B Baradaran… - Journal of cellular …, 2019 - Wiley Online Library
Zinc finger E‐box binding homeobox 2 (ZEB2) is a DNA‐binding transcription factor, which
is mainly involved in epithelial‐to‐mesenchymal transition (EMT). EMT is a conserved …

[HTML][HTML] The roles of ZEB1 in tumorigenic progression and epigenetic modifications

Y Zhang, L Xu, A Li, X Han - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with
the malignancy of various cancers. Signal transduction and activation of ZEB1 play …

Pleiotropic roles for ZEB1 in cancer

J Caramel, M Ligier, A Puisieux - Cancer research, 2018 - AACR
ZEB1 is a prime element of a network of transcription factors that controls epithelial-to-
mesenchymal transition (EMT), a reversible embryonic transdifferentiation program that …

[HTML][HTML] ZEB1: catalyst of immune escape during tumor metastasis

J Lu, F Fei, C Wu, J Mei, J Xu, P Lu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The transcription factor zinc finger E-box binding homeobox 1 (ZEB1) is a critical inducer of
epithelial mesenchymal transformation (EMT) and plays a robust role in tumor metastasis. It …

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

JE Larsen, V Nathan, JK Osborne… - The Journal of …, 2016 - Am Soc Clin Investig
Increased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with
tumor grade and metastasis in lung cancer, likely due to its role as a transcription factor in …

USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis

L Sun, J Yu, J Guinney, B Qin, FA Sinicrope - Molecular Cancer Research, 2023 - AACR
Zinc finger E-box–binding homeobox 1 (ZEB1) is a transcription factor that can promote
tumor invasion and metastasis by inducing epithelial-to-mesenchymal transition (EMT). To …

Genome–wide binding of transcription factor ZEB1 in triple‐negative breast cancer cells

V Maturi, S Enroth, CH Heldin… - Journal of Cellular …, 2018 - Wiley Online Library
Zinc finger E‐box binding homeobox 1 (ZEB1) is a transcriptional regulator involved in
embryonic development and cancer progression. ZEB1 induces epithelial‐mesenchymal …

ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

P Zhang, Y Sun, L Ma - Cell cycle, 2015 - Taylor & Francis
Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes tumor
invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma …