Objective: Abstinence outcomes are typically prioritized in the treatment of cocaine use
disorder while ignoring patterns of low-frequency cocaine use. This study examined patterns …

Background Little in known about the extent to which outcome measures used in studies of
the treatment of cocaine dependence are associated with longer-term use and with broader …

Background There is a need to identify clinically meaningful non-abstinent endpoints for
cocaine use disorder (CUD) clinical trials. In this study, we sought to replicate and extend …

Background Substantial efforts have been made to identify clinically meaningful non-
abstinence cocaine use outcomes by establishing associations between targeted drug use …

Background Despite calls for non-abstinence endpoints in randomized clinical trials (RCTs)
for cocaine use disorder, there is a lack of data validating non-abstinence endpoints. We …

We examined the ability of several baseline variables to predict treatment outcome in a
pharmacotherapy trial that included 164 participants who were both cocaine-and alcohol …

Structured treatments for cocaine dependence have been shown to be effective despite high
attrition rates. What is unclear is what level of treatment intensity is needed to improve and …

This study investigated whether alcohol use affects baseline characteristics and treatment
outcome in 128 adults who participated in a randomized trial of cognitive behavioral vs. 12 …

Objective: Cocaine users often present to treatment with a multitude of problems typically
considered addiction related; however, there is little evidence that reductions in cocaine use …

Background In clinical trials of pharmacotherapy for substance use, abstinence is the
primary endpoint accepted by regulatory agencies. However, this endpoint could be overly …