Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Cellular senescence is an important mechanism for preventing the proliferation of potential
cancer cells. Recently, however, it has become apparent that this process entails more than …

Cellular senescence is the state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …

In normal tissue, cell division is carefully regulated to maintain the correct proliferative
balance. Abnormal cell division underlies many hypoproliferative and hyperproliferative …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …

Cellular senescence, first observed and defined using in vitro cell culture studies, is an
irreversible cell cycle arrest which can be triggered by a variety of factors. Emerging …