Recent studies have demonstrated brain insulin signaling impairment and mitochondrial
dysfunction in diabetes. Hyperinsulinemia and hyperlipidemia arising from diabetes have …

Impaired adenosine monophosphate kinase (AMPK) signalling under hyperglycaemic
conditions is known to cause mitochondrial dysfunction in diabetic sensory neurons …

Symmetrical sensory polyneuropathy, the most common form of diabetic neuropathy in
humans, is associated with a spectrum of structural changes in peripheral nerve that …

Diabetic neuropathy is a major complication of diabetes that results in the progressive
deterioration of the sensory nervous system. Mitochondrial dysfunction has been proposed …

Diabetic neuropathy is a neurological complication of diabetes that causes significant
morbidity and, because of the obesity-driven rise in incidence of type 2 diabetes, is …

Diabetic neuropathy affects approximately 50% of diabetic patients. Down-regulation of
mitochondrial gene expression and function has been reported in both human tissues and in …

Current hypotheses implicate insulin resistance of the brain as a pathogenic factor in the
development of Alzheimer's disease and other dementias, Parkinson's disease, type 2 …

Mitochondrial dysfunction occurs in sensory neurons and may contribute to distal
axonopathy in animal models of diabetic neuropathy. The adenosine monophosphate …

Aims Abnormalities in mitochondrial function under diabetic conditions can lead to deficits in
function of cortical neurons and their support cells exhibiting a pivotal role in the …

Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous
system where mitochondrial dysfunction has been implicated as an etiological factor …