During the last decades, schizophrenia has been regarded as a developmental disorder.
The neurodevelopmental hypothesis proposes schizophrenia to be related to genetic and …

Objective Clinical, neuroimaging, neuropathological and neuropsychological evidence
suggests that, in schizophrenia, there is structural and functional disturbance of the …

It has become increasingly clear that the increase in corticosteroid levels, eg after a brief
stressor induce molecular and cellular changes in brain, including the hippocampal …

Stress is a common life event with potentially long lasting effects on health and behavior.
Stress, and the corticosteroid hormones that mediate many of its effects, are well known for …

Environmental stressors during childhood and adolescence influence postnatal brain
maturation and human behavioral patterns in adulthood. Accordingly, excess stressors …

A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …

Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This
may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known …

Psychiatric disorders are complex multifactorial disorders involving chronic alterations in
neural circuit structure and function. While genetic factors play a role in the etiology of …

Why do some individuals succumb to stress and develop debilitating psychiatric disorders,
whereas others adapt well in the face of adversity? There is a gap in understanding the …

Highlights•Current findings on epigenetic embedding of the long term effects of
stress.•Describe the effects of the type and timing of stress on these mechanisms.•Describe …