Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

DA Martins, N Mazibuko, F Zelaya… - Nature …, 2020 - nature.com
Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain
physiology when delivered intranasally? We address this question by contrasting two …

Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

Oxytocin's effect on resting-state functional connectivity varies by age and sex

NC Ebner, H Chen, E Porges, T Lin, H Fischer… - …, 2016 - Elsevier
The neuropeptide oxytocin plays a role in social cognition and affective processing. The
neural processes underlying these effects are not well understood. Modulation of …

Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients

SBJ Koch, M van Zuiden, L Nawijn, JL Frijling… - …, 2016 - nature.com
Post-traumatic stress disorder (PTSD) is a disabling psychiatric disorder. As a substantial
part of PTSD patients responds poorly to currently available psychotherapies …

Intranasal oxytocin normalizes amygdala functional connectivity in posttraumatic stress disorder

SBJ Koch, M van Zuiden, L Nawijn, JL Frijling… - …, 2016 - nature.com
The neuropeptide oxytocin (OT) has been suggested as a promising pharmacological agent
for medication-enhanced psychotherapy in posttraumatic stress disorder (PTSD) because of …

Oxytocin attenuates amygdala responses to emotional faces regardless of valence

G Domes, M Heinrichs, J Gläscher, C Büchel… - Biological …, 2007 - Elsevier
BACKGROUND: Oxytocin is known to reduce anxiety and stress in social interactions as
well as to modulate approach behavior. Recent studies suggest that the amygdala might be …

[HTML][HTML] A spatiotemporal profile of in vivo cerebral blood flow changes following intranasal oxytocin in humans

Y Paloyelis, OM Doyle, FO Zelaya, S Maltezos… - Biological …, 2016 - Elsevier
Background Animal and human studies highlight the role of oxytocin in social cognition and
behavior and the potential of intranasal oxytocin (IN-OT) to treat social impairment in …

Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay

MR Lee, KB Scheidweiler, XX Diao, F Akhlaghi… - Molecular …, 2018 - nature.com
Oxytocin (OT) is a potential treatment for multiple neuropsychiatric disorders. As OT is a
peptide, delivery by the intranasal (IN) route is the preferred method in clinical studies …

Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study

D Pincus, S Kose, A Arana, K Johnson… - Frontiers in …, 2010 - frontiersin.org
Background: Oxytocin is a stress-attenuating and pro-social neuropeptide. To date, no study
has looked at the effects of oxytocin in modulating brain activity in depressed individuals nor …

Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques

ME Modi, F Connor-Stroud, R Landgraf… - …, 2014 - Elsevier
Intranasal (IN) administration is a widely used method for examining the effect of oxytocin
(OT) on social behavior and cognition in healthy subjects and psychiatric populations. IN-OT …